Comment on: Toward an optimal contraception dosing strategy

doi:10.1371/journal.pcbi.1012398

. 2024 Dec 18;20(12):e1012398.

doi: 10.1371/journal.pcbi.1012398. eCollection 2024 Dec.

Comment on: Toward an optimal contraception dosing strategy

Giuseppe Benagiano^{1

2}, Andrea R Genazzani³, Giovanni Grandi⁴, Sun-Wei Guo⁵, Marwan Habiba⁶

Affiliations

¹ Faculty of Medicine and Dentistry, 'Sapienza', University of Rome, Rome, Italy.
² Geneva Foundation for Medical Education and Research, Geneva, Switzerland.
³ Division of Obstetrics and Gynecology, Department of Clinical and Experimental Medicine, The University of Pisa, Pisa, Italy.
⁴ Department of Medical and Surgical Sciences for Mother, Child and Adult, University of Modena and Reggio Emilia, Azienda Ospedaliero Universitaria Policlinico, Modena, Italy.aculty of Medicine, University of Modena, Modena, Italy.
⁵ Department of Biochemistry and Molecular Biology, Research Institute of Shanghai Obstetrics & Gynecology Hospital, Fudan University, Shanghai, China.
⁶ Department of Health Sciences, University of Leicester and University Hospitals of Leicester, Leicester, United Kingdom.

PMID: 39693279
PMCID: PMC11654926
DOI: 10.1371/journal.pcbi.1012398

Comment on: Toward an optimal contraception dosing strategy

Giuseppe Benagiano et al. PLoS Comput Biol. 2024.

. 2024 Dec 18;20(12):e1012398.

doi: 10.1371/journal.pcbi.1012398. eCollection 2024 Dec.

Authors

Giuseppe Benagiano^{1

2}, Andrea R Genazzani³, Giovanni Grandi⁴, Sun-Wei Guo⁵, Marwan Habiba⁶

Affiliations

¹ Faculty of Medicine and Dentistry, 'Sapienza', University of Rome, Rome, Italy.
² Geneva Foundation for Medical Education and Research, Geneva, Switzerland.
³ Division of Obstetrics and Gynecology, Department of Clinical and Experimental Medicine, The University of Pisa, Pisa, Italy.
⁴ Department of Medical and Surgical Sciences for Mother, Child and Adult, University of Modena and Reggio Emilia, Azienda Ospedaliero Universitaria Policlinico, Modena, Italy.aculty of Medicine, University of Modena, Modena, Italy.
⁵ Department of Biochemistry and Molecular Biology, Research Institute of Shanghai Obstetrics & Gynecology Hospital, Fudan University, Shanghai, China.
⁶ Department of Health Sciences, University of Leicester and University Hospitals of Leicester, Leicester, United Kingdom.

PMID: 39693279
PMCID: PMC11654926
DOI: 10.1371/journal.pcbi.1012398

Abstract

The optimal contraception dosing strategy proposed by Gavina et al. recently is a commendable attempt to model a complex physiological process with potenial to apply to real-life data. However, there is a need to take into account the real challenges that arise when moving from the theory to its practical application, and it is important that lessons learnt from clinical studies be taken into consideration in any theoretical modelling. In this manuscript, we spell out these lessons and elaborate practical challenges facing their model.

Copyright: © 2024 Benagiano et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Conflict of interest statement

The authors have declared that no competing interests exist.

References

1. Gavina BLA, de los Reyes VAA, Olufsen MS, Lenhart S, Ottesen JT. Toward an optimal contraception dosing strategy. PLoS Comput Biol. 2023;19: e1010073. doi: 10.1371/journal.pcbi.1010073 - DOI - PMC - PubMed
1. Sitruk-Ware R, Nath A. Characteristics and metabolic effects of estrogen and progestins contained in oral contraceptive pills. Best Pract Res Clin Endocrin Metab. 2013;27:13–24. doi: 10.1016/j.beem.2012.09.004 - DOI - PubMed
1. Pincus G, Rock J, Garcia CR, Rice-Wray E, Paniagua M, Rodriguez I. Fertility control with oral medication. Am J Obstet Gynecol. 1958;75:1333–46. doi: 10.1016/0002-9378(58)90722-1 - DOI - PubMed
1. Gallo MF, Nanda K, Grimes DA, Lopez LM, Kenneth F Schulz KF. 20 μg versus >20 μg estrogen combined oral contraceptives for contraception. Cochrane Database Syst Rev 2013;2013:CD003989. - PubMed
1. Liu S, Kciuk O, Frank M, Tyson N. Progestins of today and tomorrow. Curr Opin Obstet Gynecol. 2022;34:344–50. doi: 10.1097/GCO.0000000000000819 - DOI - PubMed

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[1] Gavina BLA, de los Reyes VAA, Olufsen MS, Lenhart S, Ottesen JT. Toward an optimal contraception dosing strategy. PLoS Comput Biol. 2023;19: e1010073. doi: 10.1371/journal.pcbi.1010073 - DOI - PMC - PubMed

[2] Gavina BLA, de los Reyes VAA, Olufsen MS, Lenhart S, Ottesen JT. Toward an optimal contraception dosing strategy. PLoS Comput Biol. 2023;19: e1010073. doi: 10.1371/journal.pcbi.1010073 - DOI - PMC - PubMed

[3] Sitruk-Ware R, Nath A. Characteristics and metabolic effects of estrogen and progestins contained in oral contraceptive pills. Best Pract Res Clin Endocrin Metab. 2013;27:13–24. doi: 10.1016/j.beem.2012.09.004 - DOI - PubMed

[4] Sitruk-Ware R, Nath A. Characteristics and metabolic effects of estrogen and progestins contained in oral contraceptive pills. Best Pract Res Clin Endocrin Metab. 2013;27:13–24. doi: 10.1016/j.beem.2012.09.004 - DOI - PubMed

[5] Pincus G, Rock J, Garcia CR, Rice-Wray E, Paniagua M, Rodriguez I. Fertility control with oral medication. Am J Obstet Gynecol. 1958;75:1333–46. doi: 10.1016/0002-9378(58)90722-1 - DOI - PubMed

[6] Pincus G, Rock J, Garcia CR, Rice-Wray E, Paniagua M, Rodriguez I. Fertility control with oral medication. Am J Obstet Gynecol. 1958;75:1333–46. doi: 10.1016/0002-9378(58)90722-1 - DOI - PubMed

[7] Gallo MF, Nanda K, Grimes DA, Lopez LM, Kenneth F Schulz KF. 20 μg versus >20 μg estrogen combined oral contraceptives for contraception. Cochrane Database Syst Rev 2013;2013:CD003989. - PubMed

[8] Gallo MF, Nanda K, Grimes DA, Lopez LM, Kenneth F Schulz KF. 20 μg versus >20 μg estrogen combined oral contraceptives for contraception. Cochrane Database Syst Rev 2013;2013:CD003989. - PubMed

[9] Liu S, Kciuk O, Frank M, Tyson N. Progestins of today and tomorrow. Curr Opin Obstet Gynecol. 2022;34:344–50. doi: 10.1097/GCO.0000000000000819 - DOI - PubMed

[10] Liu S, Kciuk O, Frank M, Tyson N. Progestins of today and tomorrow. Curr Opin Obstet Gynecol. 2022;34:344–50. doi: 10.1097/GCO.0000000000000819 - DOI - PubMed

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Comment on: Toward an optimal contraception dosing strategy

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Comment on: Toward an optimal contraception dosing strategy

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