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Review
. 2025 Feb 19;107(4):418-426.
doi: 10.2106/JBJS.24.00905. Epub 2024 Dec 18.

Skeletal Stem Cells: A Basis for Orthopaedic Pathology and Tissue Repair

Ting Cong  1   2 , Kyle W Morse  3   4 , Branden R Sosa  3   4 , Joseph M Lane  3   4 , Scott A Rodeo  3   4 , Matthew B Greenblatt  5   6
Affiliations
Review

Skeletal Stem Cells: A Basis for Orthopaedic Pathology and Tissue Repair

Ting Cong et al. J Bone Joint Surg Am. .

Abstract

➢ Skeletal stem cells (SSCs) continually replenish mature cell populations to support skeletal homeostasis.➢ SSCs repopulate by self-renewal, have multilineage potential, and are long-lived in vivo.➢ SSCs express specific combinations of cell surface markers that reflect their lineage identity.➢ SSCs adapt to their anatomic environment to support regional differences in skeletal behavior and pathology.

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Conflict of interest statement

Disclosure: Matthew B. Greenblatt is supported by the National Institutes of Health (NIH) under awards R01AR075585, R01HD115274, and R01CA282815, a Career Award for Medical Scientists from the Burroughs Welcome Foundation, a Marfan Foundation Innovator Award, the Mary Kay Ash Foundation, the Mathers Foundation, and a Pershing Square Foundation MIND Prize. The Disclosure of Potential Conflicts of Interest forms are provided with the online version of the article ( http://links.lww.com/JBJS/I321 ).

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