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. 2025 Feb 12;6(1):zqae055.
doi: 10.1093/function/zqae055.

STIMulating Salivary Glands

Karla M Márquez-Nogueras  1 , Ivana Y Kuo  1
Affiliations

STIMulating Salivary Glands

Karla M Márquez-Nogueras et al. Function (Oxf). .
No abstract available

PubMed Disclaimer

Conflict of interest statement

None declared.

Figures

Figure 1.
Figure 1.
The Role of STIM1/2 in the Production of Saliva. Left Top: The inflammatory-salivation model most associated with Sjorden's Disease (SjD). Left Bottom: Representation of the proposed model from Son and colleagues. Son and colleagues show that agonist-activated calcium signaling (Number 1 in the right side panel) is diminished with STIM1/2 KO (Number 2), which reduces calcium-activated chloride currents and salivary production (Number 3). The STIM1/2 KO mouse model does not have an immune infiltration phenotype. Abbreviations: ANO1: Calcium-activated Chloride Channel, AQP5: Aquaporin 5, InsP3R: Inositol Trisphosphate Receptor, M3R: Muscarinic Receptor.
See this image and copyright information in PMC

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