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Editorial
. 2025 Mar;87(3):364-367.
doi: 10.1016/j.eururo.2024.12.003. Epub 2024 Dec 17.

Optimal Treatment Strategies for Hormone-sensitive Metastatic Prostate Cancer: Does Local Radiotherapy Play a Role in High-volume Disease?

Steven Tisseverasinghe  1 , Marwan Tolba  2 , Fred Saad  3 , Karim Fizazi  4 , Boris Bahoric  5 , Tamim Niazi  6
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Editorial

Optimal Treatment Strategies for Hormone-sensitive Metastatic Prostate Cancer: Does Local Radiotherapy Play a Role in High-volume Disease?

Steven Tisseverasinghe et al. Eur Urol. 2025 Mar.

Abstract

Optimal treatment strategies for metastatic hormone-sensitive prostate cancer (mHSPC) are evolving with novel multimodal approaches. For well-selected patients, early local radiotherapy can play a pivotal role in high-volume mHSPC. Radiotherapy controls local disease, reduces symptoms, and may potentially delay castration resistance, warranting its consideration alongside systemic therapies in high-volume mHSPC.

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