Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Dec 18;24(1):3458.
doi: 10.1186/s12889-024-21013-7.

Prioritizing vaccine introduction to China's National Immunization Program: a multi-criteria decision analysis

Jianming Guo  1   2   3 , Bin Zheng  2 , Tingting Chen  2 , Shuyan Guo  3 , Maobai Liu  4 , Siping Dong  5   6   7
Affiliations

Prioritizing vaccine introduction to China's National Immunization Program: a multi-criteria decision analysis

Jianming Guo et al. BMC Public Health. .

Abstract

Background: To prioritize the introducing of new vaccines into China's National Immunization Program (NIP) among 10 candidate vaccines across four classes.

Methods: We developed a vaccine value framework using Multi-Criteria Decision Analysis (MCDA) to simulate the introduction of new vaccines into NIP, covering 21 criteria encompassing six dimensions: safety, effectiveness, economy, innovation, accessibility, and appropriateness. Two decision scenarios were considered: Scenario One prioritized the four classes of vaccines, while Scenario Two identified specific vaccines within each class.

Results: In the vaccine value framework, safety received the highest weight, while innovation received the lowest. The Human Papillomavirus (HPV) vaccine was identified as a top priority for inclusion in NIP, followed by Pneumococcal Conjugate Vaccine (PCV), Haemophilus Influenzae Type B (HIB), and Rotavirus (RV) vaccines. The specific types are domestic bivalent HPV vaccine, imported 13-valent PCV vaccine, domestic HIB vaccine, and domestic RV vaccine. The results of the one-way and probabilistic sensitivity analysis demonstrated robustness.

Conclusions: This study provides a transparent, comprehensive, and quantifiable vaccine value framework to aid decision-making for introducing new vaccines into China's NIP. According to the MCDA results, HPV should be considered the top vaccine candidate for the NIP.

Keywords: China; Multi-criteria decision analysis; National immunization program; Vaccines.

PubMed Disclaimer

Conflict of interest statement

Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: All authors were informed about intent to publish results. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Weighting of each criterion
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Koff WC, Burton DR, Johnson PR, Walker BD, King CR, Nabel GJ, et al. Accelerating next-generation vaccine development for global disease prevention. Science. 2013;340(6136):1232910. - PMC - PubMed
    1. Timmis JK, Black S, Rappuoli R. Improving accountability in vaccine decision-making. Expert Rev Vaccines. 2017;16(11):1057–66. - PubMed
    1. Hamilton K, Baron MD, Matsuo K, Visser D. Rinderpest eradication: challenges for remaining disease free and implications for future eradication efforts. Rev Sci Tech. 2017;36(2):579–88. - PubMed
    1. Kumar Suri R, Hayman B, Prasad SD, Makhoana M, Tippoo P. Vaccines: new challenges, new paradigms, new opportunities: report of the 22nd DCVMN Annual General Meeting. Vaccine. 2022;40(26):3495–505. - PMC - PubMed
    1. Ikilezi G, Augusto OJ, Dieleman JL, Sherr K, Lim SS. Effect of donor funding for immunization from Gavi and other development assistance channels on vaccine coverage: evidence from 120 low and middle income recipient countries. Vaccine. 2020;38(3):588–96. - PubMed

MeSH terms

LinkOut - more resources