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Observational Study
. 2024 Dec 18;24(1):3524.
doi: 10.1186/s12889-024-21098-0.

Possible impact of antioxidant intake on composite dietary antioxidant index and the progression of benign prostatic hyperplasia: an observational study

Xuanyu Hao  1 , Dongyang Li  2
Affiliations
Observational Study

Possible impact of antioxidant intake on composite dietary antioxidant index and the progression of benign prostatic hyperplasia: an observational study

Xuanyu Hao et al. BMC Public Health. .

Abstract

Objective: We aim to evaluate the association of composite dietary antioxidant index (CDAI) and Benign Prostatic Hyperplasia (BPH) in a large population in the United States using a cross-sectional design.

Methods: Data was retrieved from the National Health and Nutrition Examination Survey (NHANES) 2003-2008 and 2013-2020 datasets. Univariate and multivariate logistic regression were performed to explore the association between CDAI and BPH. The restricted cubic spline (RCS) model was also conducted to investigate the potential linear relationship. Sub-group analyses were also conducted.

Results: Totally, this study included 13,419 participants with 1085 BPH patients among them. The higher continuous CDAI value was significantly related to higher BPH risk (OR = 1.05, 95%CI: 1.02, 1.08). Besides, individuals with the highest quartile (Q4) CDAI possessed 1.87 times risk of BPH than the lowest quartile (Q1, OR = 1.87, 95%CI: 1.41, 2.50). The RCS curve also showed a positive linear dose-response relationship between CDAI and BPH (cut-off = -0.64). The P for interaction in any subgroup was > 0.05, indicating that the main outcome was not affected by other covariates. The limitation of this study was the lack of data on the relationship between CDAI and the severity of BPH symptoms.

Conclusions: This study reveals that an elevated CDAI may be associated with a linear higher risk of BPH. We do not recommend intentional or excessive antioxidant diet to prevent BPH based on the current results.

Keywords: Antioxidant; BPH; CDAI; Dose-response; Risk.

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: This study used publicly available data and did not require ethical approval and consent to participate. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Flaw chart of the participant collection from the NHANES 2003–2008 and 2013–2020. NHANES National Health and Nutrition Examination Survey
Fig. 2
Fig. 2
Linear restricted cubic spline (RCS) plot between CDAI and BPH. Cut-off value of CDAI = -0.64. CDAI: combined dietary antioxidant index; OR: odds ratio. The red line indicates the dose-response relationship between CDAI and BPH and the pink area represents the 95% confidence interval
See this image and copyright information in PMC

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