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. 2024 Dec 18;13(1):119.
doi: 10.1186/s13741-024-00474-9.

Excess hospital length of stay and extra cost attributable to primary prolonged postoperative ileus in open alimentary tract surgery: a multicenter cohort analysis in China

Jianning Song  1   2 , Yingchi Yang  3   4 , Wenxian Guan  5 , Gang Jin  6 , Yin Yang  7 , Lin Chen  8 , Yong Wan  9 , Zhongtao Zhang  1   2
Affiliations

Excess hospital length of stay and extra cost attributable to primary prolonged postoperative ileus in open alimentary tract surgery: a multicenter cohort analysis in China

Jianning Song et al. Perioper Med (Lond). .

Abstract

Background: Prolonged postoperative ileus (PPOI) reportedly leads to compromised postoperative recovery and increased healthcare costs. However, the evidence for this claim was obtained from studies that included patients with both primary and secondary PPOI. How primary PPOI affects the hospital length of stay (LOS) and healthcare costs is not well documented. A multicenter cohort analysis was performed to investigate the potentially detrimental effect of primary PPOI on hospital LOS and healthcare costs.

Methods: In total, 2083 patients who underwent open abdominal surgery from 22 tertiary hospitals in China were prospectively registered in a PPOI cohort. Of these, 1863 patients without secondary PPOI were analyzed. Poisson regression for hospital LOS and log-transformed linear regression for healthcare costs were performed to identify whether primary PPOI was an independent risk factor.

Results: The incidence of primary PPOI was 13.2% (246/1863). The median LOS was significantly longer in the PPOI than non-PPOI group (12 vs. 11 days, p < 0.001). The median healthcare cost was significantly higher in the PPOI than non-PPOI group (70,672 vs. 67,597 CNY, p = 0.016). Multivariate Poisson regression and log-transformed linear regression showed that 12% of prolonged LOS and 4.6% of healthcare costs were due to primary PPOI.

Conclusions: Primary PPOI is a potential source of prolonged hospital LOS and extra healthcare costs for patients undergoing open abdominal surgery. Cost-effective approaches are needed to manage and prevent primary PPOI.

Keywords: Alimentary tract surgery; Healthcare cost; Hospital length of stay; Primary postoperative prolonged ileus.

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: This PPOI cohort study was approved by the Ethics Committee of Beijing Friendship Hospital (approval code: 2016‐P2‐064‐01). The study was registered on the Chinese Clinical Trial Registry website (registry ID: ChiCTR‐IOC‐16009955) ( http://www.chictr.org.cn/showproj.aspx?proj=16810 ). Consent for publication: It has been confirmed all authors agreed to submit the article. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Flow chart of study population selection. This flow diagram shows study population selection in PPOI cohort according to specific inclusion and exclusion criteria. Finally, 1863 primary patients with complete hospital length of stay and healthcare cost were included for analysis
See this image and copyright information in PMC

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References

    1. Asgeirsson T, El-Badawi KI, Mahmood A, Barletta J, Luchtefeld M, Senagore AJ. Postoperative ileus: it costs more than you expect. J Am Coll Surg. 2010;210:228–31. 10.1016/j.jamcollsurg.2009.09.028. - PubMed
    1. Bell TJ, Poston SA, Kraft MD, Senagore AJ, Delaney CP, Techner L. Economic analysis of alvimopan in North American Phase III efficacy trials. Am J Health Syst Pharm. 2009;66:1362–8. 10.2146/ajhp080329. - PubMed
    1. Boitano TKL, Smith HJ, Rushton T, Johnston MC, Lawson P, Leath CA, Xhaja A, Guthrie MP, Straughn JM. Impact of enhanced recovery after surgery (ERAS) protocol on gastrointestinal function in gynecologic oncology patients undergoing laparotomy. Gynecol Oncol. 2018;151:282–6. 10.1016/j.ygyno.2018.09.009. - PubMed
    1. Delaney C. Postoperative ileus: profiles, risk factors, and definitions a framework for optimizing surgical outcomes in patients undergoing major abdominal and colorectal surgery. In: Bosker G, editor. Clinical Consensus Update in General Surgery. Roswell (GA): Pharmatecture, LLC; 2006.
    1. de Leede EM, van Leersum NJ, Kroon HM, van Weel V, van der Sijp JRM, Bonsing BA, Woltz S, Tromp M, Neijenhuis PA, Maaijen RCLA, Steup WH, Schepers A, Guicherit OR, Huurman VAL, Karsten TM, van de Pool A, Boerma D, Deroose JP, Beek M, Wijsman JH, Derksen WJM, Festen S, de Nes LCF. Multicentre randomized clinical trial of the effect of chewing gum after abdominal surgery. Br J Surg. 2018;105:820–8. 10.1002/bjs.10828. - PubMed

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