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. 1985 Feb;160(2):105-8.

Bacterial inoculum and the activity of antimicrobial agents

D E Fry, R N Garrison, L Trachtenberg, H C Polk Jr
  • PMID: 3969604

Bacterial inoculum and the activity of antimicrobial agents

D E Fry et al. Surg Gynecol Obstet. 1985 Feb.

Abstract

Experimental and clinical infections have concentrations of bacteria that are greater than the concentrations used in the laboratory for the determination of in vitro activity. When realistic concentrations are used, the antibiotic activity is reduced. The optimum selection of antibiotics may require a re-examination of the laboratory procedures for the determination of sensitivity data.

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