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. 2024 Dec 18;23(1):375.
doi: 10.1186/s12936-024-05178-5.

Microscopic prevalence and risk factors of asymptomatic malaria in Gorgora, western Dembia, Northwest Ethiopia: exploring hidden threats during minor transmission season

Tena Cherkos  1 , Adane Derso  2 , Wossenseged Lemma  2 , Aberham Abere  2 , Teshiwal Deress  3 , Banchamlak Tegegne  4 , Gebeyaw Getnet Mekonnen  2 , Abebe Birhanu  5 , Yalewayker Tegegne  2
Affiliations

Microscopic prevalence and risk factors of asymptomatic malaria in Gorgora, western Dembia, Northwest Ethiopia: exploring hidden threats during minor transmission season

Tena Cherkos et al. Malar J. .

Abstract

Background: Malaria poses a significant public health threat globally, particularly in African regions, where asymptomatic malaria is a considerable logistic problem. Individuals with asymptomatic malaria do not seek treatment, and thus they are invisible to health facilities and represent a substantial hidden reservoir of Plasmodium species. This study aimed to determine the prevalence of asymptomatic malaria and its associated factors in Gorgora, western Dembia district, Northwest Ethiopia.

Methods: A community-based cross-sectional study was conducted from May to June 2023 in the Gorgora area, Western Dembia district, Northwest Ethiopia. Data were collected using a semi-structured questionnaire. Giemsa-stained blood smear microscopy was employed for the diagnosis of Plasmodium species. The data were entered into Epi Data version 4.6 and exported to SPSS version 25 for analysis. Bivariate and multivariable binary logistic regression analyses were conducted to identify associated factors.

Results: Among the 357 individuals who participated in this study, 9.2% (33/357) [95% CI 6.40-12.70: p = 0.000] were confirmed to be infected with Plasmodium species. Plasmodium falciparum and Plasmodium vivax accounted for 66.7% and 33.3%, respectively. Not using bed nets [AOR = 7.3, 95% CI 2.08-23.46, p = 0.006)], previous malaria history [AOR = 2.6, 95% CI 1.01-6.45, p = 0.041], outdoor activities at night [AOR = 8.3, 95% CI 3.21-21.30, p = 0.000], and family size [AOR = 3.3, 95% CI 1.18-9.22, p = 0.023] were significantly associated with asymptomatic malaria (p < 0.05).

Conclusions: A considerable proportion of asymptomatic Plasmodium infections was found which likely act as a reservoir of transmission. This has implications for ongoing malaria control programmes that are based on the treatment of symptomatic patients and highlight the need for intervention strategies targeting asymptomatic carriers. Not using bed nets, engaging in outdoor activities at night, and having a family size of more than five increased the odds of developing asymptomatic malaria. The district health office and health extension workers should collaborate to promote the regular use of mosquito bed nets among community residents.

Keywords: Associated factors; Asymptomatic malaria; Gorgora; Prevalence.

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: Prior to commencing the study, ethical clearance was obtained from the ethical review committee of the School of Biomedical and Laboratory Sciences, University of Gondar, with reference number SBMLS/516. Additionally, permission was obtained from the Western Dembia district health office and Kebele administrators, where the data were collected. Written informed consent was obtained from eligible study participants who willingly agreed to be part of the study after being informed about the purpose, procedures, benefits, and risks involved. For eligible children, verbal assent was sought before obtaining written informed consent from their parents/legal guardians. The study participants were informed that participation in the study was voluntary, and the confidentiality of their information was ensured by using codes instead of names and identification in the data collection form. Finally, malaria-positive asymptomatic study participants were referred to nearby health centers for appropriate treatment. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Map of the study site at Western Dembia District, Northwest Ethiopia. N: number of households in the Kebele. n: selected household in the kebele
Fig. 2
Fig. 2
Schematic presentation of sampling procedure
Fig. 3
Fig. 3
Prevalence of asymptomatic malaria in Gorgora, western Dembia, Northwest Ethiopia
See this image and copyright information in PMC

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