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Review
. 2025 May;64(5):819-829.
doi: 10.1111/ijd.17580. Epub 2024 Dec 19.

Premature hair graying: a multifaceted phenomenon

Deesha D Desai  1   2 , Maria Karim  1 , Ambika Nohria  1 , Carli Needle  1 , Anna Brinks  1 , Caitlin A Kearney  1 , Amy Ridge  3 , Natasha Mesinkovska  4 , Jerry Shapiro  1 , Kristen I Lo Sicco  1
Affiliations
Review

Premature hair graying: a multifaceted phenomenon

Deesha D Desai et al. Int J Dermatol. 2025 May.

Abstract

Premature hair graying (PHG) is the early loss of natural hair color, influenced by genetic, biological, and environmental factors. This review discusses the significant psychological impacts of PHG and explores its underlying mechanisms, related health conditions, and available treatments. The review examines the roles of genetics, oxidative stress, and lifestyle factors such as smoking and diet in premature graying. It also considers associated medical conditions and current and emerging treatment options. This overview aims to improve understanding of PHG and its broader implications.

Keywords: PHG; early graying; hair; hair pigmentation; premature graying.

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Figures

Figure 1
Figure 1
Spatial distribution of graying for men.
Figure 2
Figure 2
Spatial distribution of graying for women.
See this image and copyright information in PMC

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