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Review
. 2025 Dec;22(1):1-8.
doi: 10.1080/15476286.2024.2440678. Epub 2024 Dec 19.

The role and function of lncRNA in ageing-associated liver diseases

Peyman Kheirandish Zarandi  1   2 , Mohsen Ghiasi  3 , Mohammad Heiat  4
Affiliations
Review

The role and function of lncRNA in ageing-associated liver diseases

Peyman Kheirandish Zarandi et al. RNA Biol. 2025 Dec.

Abstract

Liver diseases are a significant global health issue, characterized by elevated levels of disorder and death. The substantial impact of ageing on liver diseases and their prognosis is evident. Multiple processes are involved in the ageing process, which ultimately leads to functional deterioration of this organ. The process of liver ageing not only renders the liver more susceptible to diseases but also compromises the integrity of other organs due to the liver's critical function in metabolism regulation. A growing body of research suggests that long non-coding RNAs (lncRNAs) play a significant role in the majority of pathophysiological pathways. They regulate gene expression through a variety of interactions with microRNAs (miRNAs), messenger RNAs (mRNAs), DNA, or proteins. LncRNAs exert a major influence on the progression of age-related liver diseases through the regulation of cell proliferation, necrosis, apoptosis, senescence, and metabolic reprogramming. A concise overview of the current understanding of lncRNAs and their potential impact on the development of age-related liver diseases will be provided in this mini-review.

Keywords: Liver diseases; ageing; liver ageing; lncRNAs; ncRNAs.

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Conflict of interest statement

No potential conflict of interest was reported by the author(s).

Figures

Figure 1.
Figure 1.
The impact of ageing on liver function and its role in disorders affecting the skeletal, neurological, and cardiovascular systems.
Figure 2.
Figure 2.
Differentially expressed lncRNAs in ageing-associated liver and their function.
See this image and copyright information in PMC

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