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. 2024 Dec 3:14:1454844.
doi: 10.3389/fonc.2024.1454844. eCollection 2024.

The role of FDG PET assessment in patients with advanced breast cancer treated with cyclin-dependent kinase 4/6 inhibitors in the second-line setting

Marcin Kubeczko  1 , Anna Polakiewicz-Gilowska  1 , Andrea D'Amico  2 , Olgierd Chrabański  2 , Katarzyna Świderska  1 , Ewa Chmielik  3 , Sławomir Blamek  4 , Daria Handkiewicz-Junak  2 , Michał Jarząb  1
Affiliations

The role of FDG PET assessment in patients with advanced breast cancer treated with cyclin-dependent kinase 4/6 inhibitors in the second-line setting

Marcin Kubeczko et al. Front Oncol. .

Abstract

Background: Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors have demonstrated a survival benefit in the second-line treatment of patients with hormone receptor-positive human epidermal growth factor receptor 2-negative advanced breast cancer. However, identifying prognostic biomarkers remains a challenge. Thus, we aimed to assess the prognostic value of 18F-fluorodeoxyglucose positron emission tomography-computed tomography (FDG-PET-CT) performed before CDK4/6 inhibitors initiation.

Methods: This single-center retrospective analysis comprised patients treated with CDK4/6 inhibitors in the second-line setting between 2018 and 2024, with FDG-PET-CT performed before CDK4/6 inhibitor initiation.

Results: The study included 39 patients with a median age of 63 years (IQR 50 -71). Among them, 12 had de novo metastatic disease (30.8%), and 13 had oligometastatic disease (33.3%). Treatment distribution was as follows: 15 patients received palbociclib (38%), 19 ribociclib (49%), and five abemaciclib (13%). Most patients received fulvestrant (31 patients, 79%), whereas eight patients (21%) were treated with letrozole. The median progression-free survival (PFS) in all studied patients was 25.8 months. Notably, baseline SUVmax (maximum standardized uptake value) showed statistically and clinically significant differences. Patients in the low SUVmax group had a median PFS of 30.7 months, compared to 13.0 months for those in the high SUVmax group (p = 0.038). The 2-year PFS was 76.2% [95% CI 51.8% - 89.4%] for the low SUVmax group, contrasting with 22.3% [95% CI 4.0% - 49.9%] for the high SUVmax group. High SUVmax, poor performance status, and de novo metastatic disease were independent prognostic factors for PFS.

Conclusions: FDG-PET-CT performed before cyclin-dependent kinase 4/6 inhibitor commencement is a valuable prognostic tool in hormone receptor-positive human epidermal growth factor receptor 2-negative advanced breast cancer. Patients with SUVmax less than 8.4 experienced extended progression-free survival compared to those with higher SUVmax.

Keywords: 18Ffluorodeoxyglucose positron emission tomography; abemaciclib; advanced breast cancer; palbociclib; ribociclib.

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Conflict of interest statement

MK declares advisory board for Novartis; speaker's honoraria from Novartis, Roche, MSD, Pfizer, Lilly, Teva, Amgen, Swixx Biopharma, and Gilead; clinical trials for Roche, MSD, Novartis, Seagen, and Gilead; conference fees for Pfizer, Roche, Novartis, Teva, Amgen, Gilead, MSD, and Swixx Biopharma; all outside the submitted work. AP-G declares conferences fees for Pfizer, clinical trials for Roche, MSD, Novartis, Seagen, Gilead; speaker's honorarium: Pfizer, Novartis, Gilead; all outside the submitted work. KS declares conferences fees: Novartis, clinical studies: Roche, MSD, Novartis; speaker's honorarium: Novartis; all outside the submitted work. MJ declares conference fees for Gilead, Roche; clinical trials for Roche, MSD, Novartis, Seagen, and Gilead; speaker's honoraria from Novartis, Roche, Lilly, Pfizer, Teva, Exact Sciences, Mammotome, and Gilead; advisory boards for Novartis and Pfizer; all outside submitted work. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
PET scan in hot iron color scale of a patient from the low SUVmax group (SUVmax 7.8), demonstrating multiple visceral and bone metastases, including metastases to the liver, lungs, pleura, bones, and lymph nodes.
Figure 2
Figure 2
PET scan in hot iron color scale of a patient from the high SUVmax group (SUVmax 24.4), showing primarily bone metastases, along with metastases to the pleura and internal mammary lymph nodes.
Figure 3
Figure 3
Kaplan-Meier curves for progression-free survival of patients treated with cyclin-dependent kinase 4/6 inhibitors in the second-line setting with a comparison between low SUVmax group (defined as baseline SUVmax <8.4) and high SUVmax group (defined as baseline SUVmax ≥ 8.4).
Figure 4
Figure 4
Duration of response to cyclin-dependent kinase 4/6 inhibitors therapy among studied patients. Arrows indicate ongoing treatment.
Figure 5
Figure 5
Kaplan-Meier curves for overall survival of patients treated with cyclin-dependent kinase 4/6 inhibitors in the second-line setting with a comparison between low SUVmax group (defined as baseline SUVmax <8.4) and high SUVmax group (defined as baseline SUVmax ≥ 8.4).
See this image and copyright information in PMC

References

    1. Cardoso F, Paluch-Shimon S, Senkus E, Curigliano G, Aapro MS, André F, et al. . 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5). Ann Oncol. (2020) 31:1623–49. doi: 10.1016/j.annonc.2020.09.010 - DOI - PMC - PubMed
    1. Gennari A, André F, Barrios CH, Cortés J, de Azambuja E, DeMichele A, et al. . ESMO Clinical Practice Guideline for the diagnosis, staging and treatment of patients with metastatic breast cancer. Ann Oncol Off J Eur Soc Med Oncol. (2021) 32:1475–95. doi: 10.1016/J.ANNONC.2021.09.019 - DOI - PubMed
    1. Sledge GW, Toi M, Neven P, Sohn J, Inoue K, Pivot X, et al. . MONARCH 2: Abemaciclib in combination with fulvestrant in women with HR+/HER2- advanced breast cancer who had progressed while receiving endocrine therapy. J Clin Oncol. (2017) 35:2875–84. doi: 10.1200/JCO.2017.73.7585 - DOI - PubMed
    1. Turner NC, Slamon DJ, Ro J, Bondarenko I, Im SA, Masuda N, et al. . Overall survival with palbociclib and fulvestrant in advanced breast cancer. N Engl J Med. (2018) 379:1926–36. doi: 10.1056/NEJMOA1810527/SUPPL_FILE/NEJMOA1810527_DATA-SHARING.PDF - DOI - PubMed
    1. Slamon DJ, Neven P, Chia S, Fasching PA, De Laurentiis M, Im SA, et al. . Phase III randomized study of ribociclib and fulvestrant in hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer: MONALEESA-3. J Clin Oncol. (2018) 36:2465–72. doi: 10.1200/JCO.2018.78.9909 - DOI - PubMed

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