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Case Reports
. 2024 Dec 3;20(2):1200-1204.
doi: 10.1016/j.radcr.2024.11.036. eCollection 2025 Feb.

A case of right fronto-parietal gliosarcoma

Na Li  1 , Wangsheng Chen  1
Affiliations
Case Reports

A case of right fronto-parietal gliosarcoma

Na Li et al. Radiol Case Rep. .

Abstract

Gliosarcoma (GS) is a rare subtype of glioblastoma multiforme, characterized by a shorter clinical course and poorer prognosis compared to glioblastoma. Here, we report the case of a 50-year-old male patient who presented with episodic loss of consciousness and left-sided limb weakness for one month. MRI revealed a complex neoplastic lesion in the right fronto-parietal region. Postoperative pathology confirmed GS, and the patient underwent adjuvant radiotherapy and chemotherapy. This case highlights the characteristic features of GS through a combination of imaging and pathological findings, providing valuable insights for radiologists.

Keywords: Gliosarcoma; Intracranial tumor; Magnetic resonance imaging; Right fronto-parietal lobe.

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Figures

Fig 1
Fig. 1
MRI images. (A-E) Axial T1WI, T2WI, T2-FLAIR, DWI, and ADC images, respectively; (F-H) Axial and sagittal contrast-enhanced scans. The images reveal nodular and mass-like lesions in the right fronto-parietal lobe, displaying hypointense T1 and slightly hyperintense T2 signals, with extensive peritumoral edema (yellow arrow). Contrast-enhanced images show significant enhancement, with cystic and necrotic areas visible within the lesion (blue arrow). There is a clear mass effect and infiltration of the adjacent dura mater (red arrow). On DWI, part of the lesion exhibits mild diffusion restriction (green arrow).
Fig 2
Fig. 2
Magnetic resonance spectroscopy (MRS). MRS shows a marked elevation of the Cho peak and a reduction in the NAA peak in the right frontal lesion. The Cho/NAA ratio is 26.57, the NAA/Cr ratio is 0.18, and the Cho/Cr ratio is 4.87, indicating neuronal cell damage.
Fig 3
Fig. 3
Pathological examination. (A) Tumor cells are diffusely arranged in sheets, exhibiting spindle or ovoid shapes with significant nuclear atypia, some with eosinophilic nucleoli, and frequent mitotic figures (HE, × 40); (B) Immunohistochemical staining: Tumor cells are focally positive for GFAP (× 20); (C) Immunohistochemical staining: Tumor cells are positive for Vim (× 20).
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