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. 2024 Dec 18;17(12):2265-2275.
doi: 10.18240/ijo.2024.12.15. eCollection 2024.

Predictive value of CA-153, CA-125 and Apo A for ocular metastasis in menopausal female patients with breast cancer

Qun-Ce Liu  1 , Qian Ling  2 , Yan-Mei Zeng  2 , Cheng Chen  2 , Hong Wei  2 , Jin-Yu Hu  2 , Jie Zou  2 , Xiao-Yu Wang  2 , Xu Chen  3 , Yi Shao  2   4
Affiliations

Predictive value of CA-153, CA-125 and Apo A for ocular metastasis in menopausal female patients with breast cancer

Qun-Ce Liu et al. Int J Ophthalmol. .

Abstract

Aim: To establish a meaningful standard for diagnosing ocular metastasis (OM) in menopausal breast cancer (BC) women, and explore the relationship between CA-153, CA-125, apolipoprotein A, and OM.

Methods: A total of 1362 menopausal female BC patients with OM volunteered to take part in this study between July 2012 and July 2022. Women with BC who are menopausal were found to have an OM incidence of 1.6%. Furthermore, CA-153, CA-125, and apolipoprotein A (Apo A) all contributed to OM in women with BC who are postmenopausal according to binary logistic regression. Receiver operating curve (ROC) analysis was used to assess the diagnostic value of OM in patients with BC.

Results: Both CA-153 and CA-153+CA-125 showed a higher sensitivity of 95.45%, whereas CA-153+Apo A illustrated the highest specificity of 99.02%. Moreover, CA-153 and CA-153+CA-125 had higher areas under the curve (AUC) of 0.973.

Conclusion: The data indicate that the serum concentrations of CA-153 exhibited the most significant predictors of the diagnosis of OM in menopausal women with BC. The current study researches the utility of risk factors in predicting of OM in menopausal BC women and put forward the latest suggestions on their clinical application.

Keywords: CA-125; CA-153; apolipoprotein A; breast cancer; menopausal female patients; ocular metastasis.

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Conflict of interest statement

Conflicts of Interest: Liu QC, None; Ling Q, None; Zeng YM, None; Chen C, None; Wei H, None; Hu JY, None; Zou J, None; Wang XY, None; Chen X, None; Shao Y, None.

Figures

Figure 1
Figure 1. An example of breast cancer patients with OM
A: Ophthalmic B-type ultrasound; B: Fundus photography; C: Fundus fluorescein angiography; D: Indocyanine green angiography. OM: Ocular metastasis.
Figure 2
Figure 2. The HE and IHC staining images of OM in breast cancer patients
A: CD56; B: HE; C: SYN; D: TTF-1. HE: Hematoxylin-eosin staining; IHC: Immunohistochemistry; OM: Ocular metastasis; SYN: Synaptophysin; TTF: Thyroid transcription factor.
Figure 3
Figure 3. The drinking and non-drinking proportion of menopausal female breast cancer patients with OM or NOM
OM: ocular metastasis; NOM: Non-ocular metastasis.
Figure 4
Figure 4. ROC curves of single risk factors and the combinations of risk factors for detecting OM in menopausal female patients with breast cancer
ROC curves of CA-125, CA-153 and apolipoprotein A as single risk factor and the combination of CA-125, CA-153 and apolipoprotein A to detected OM in menopausal female patients with breast cancer. ROC: Receiver operating characteristic; AUC: Area under curve; OM: Ocular metastasis.
See this image and copyright information in PMC

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