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Multicenter Study
. 2024 Nov 29:15:1420088.
doi: 10.3389/fendo.2024.1420088. eCollection 2024.

Serum 25-hydroxy vitamin D level is associated with elastography-detected liver fibrosis in patients with type 2 diabetes mellitus in China

Nan Huang #  1   2 , Xianghui Su #  3 , Ting Yu #  4 , Xiaodong Wu  1   2 , Bing Lu  5 , Weixia Sun  1   2 , Liqin Yao  6 , Maoyun Wang  7 , Yao Wang  6 , Wenxuan Wu  6 , Yingzhao Liu  8 , Ting Yang  1 , Ruidong Gao #  7 , Congqing Miao #  9 , Ling Li #  1   2
Affiliations
Multicenter Study

Serum 25-hydroxy vitamin D level is associated with elastography-detected liver fibrosis in patients with type 2 diabetes mellitus in China

Nan Huang et al. Front Endocrinol (Lausanne). .

Abstract

Objective: In this cross-sectional study including patients with type 2 diabetes mellitus (T2DM) we aimed to explore the relationship between serum 25-hydroxy vitamin (25(OH)D) level and liver steatosis and fibrosis in the Chinese population.

Methods: Patients visiting 16 clinical centers with T2DM were recruited. Their liver steatosis and fibrosis status were then assessed using elastography. Factors associated with steatosis and fibrosis were explored using regression analysis. Correlations between serum 25(OH)D levels and other patient characteristics were analyzed using linear regression.

Results: In total, 1,513 patients with T2DM were included in the study. The prevalence of steatosis and fibrosis was 69.7%, and 34.6%, separately. A lower level of 25(OH)D was detected in patients with liver steatosis compared to those without, although it was not an independent predictor of this condition. However, 25(OH)D level was independently associated with liver fibrosis even when adjusted for age, sex, body mass index, hemoglobin A1c, insulin, and homeostatic model assessment of insulin resistance (OR = 0.964 [0.935-0.993], P = 0.015). When patients were separated into subgroups by sex, a correlation between 25(OH)D and fibrosis was identified in the male group (OR = 0.969 [0.940-0.998], P = 0.038).

Conclusions: In conclusion, this multi-center, cross-sectional study in patients with T2DM showed that serum 25-hydroxy vitamin D level was strongly associated with liver fibrosis and this relationship was more pronounced in male patients.

Clinical trial registration: https://clinicaltrials.gov/ct2/show/, identifier NCT05597709.

Keywords: 25-hydroxy vitamin D; body mass index; liver fibrosis; liver steatosis; type 2 diabetes mellitus.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

    1. Castera L, Laouenan C, Vallet-Pichard A, Vidal-Trecan T, Manchon P, Paradis V, et al. . High prevalence of NASH and advanced fibrosis in type 2 diabetes: A prospective study of 330 outpatients undergoing liver biopsies for elevated ALT, using a low threshold. Diabetes Care. (2023) 46(7):1354–62. doi: 10.2337/dc22-2048 - DOI - PubMed
    1. Furuta K, Tang X, Islam S, Tapia A, Chen ZB, Ibrahim SH. Endotheliopathy in the metabolic syndrome: Mechanisms and clinical implications. Pharmacol Ther. (2023) 244:108372. doi: 10.1016/j.pharmthera.2023.108372 - DOI - PMC - PubMed
    1. Eslam M, El-Serag HB, Francque S, Sarin SK, Wei L, Bugianesi E, et al. . Metabolic (dysfunction)-associated fatty liver disease in individuals of normal weight. Nat Rev Gastroenterol hepatology. (2022) 19(10):638–51. doi: 10.1038/s41575-022-00635-5 - DOI - PubMed
    1. Ajmera V, Cepin S, Tesfai K, Hofflich H, Cadman K, Lopez S, et al. . A prospective study on the prevalence of NAFLD, advanced fibrosis, cirrhosis and hepatocellular carcinoma in people with type 2 diabetes. J hepatology. (2023) 78(3):471–8. doi: 10.1016/j.jhep.2022.11.010 - DOI - PMC - PubMed
    1. LoMonaco R, Godinez Leiva E, Bril F, Shrestha S, Mansour L, Budd J, et al. . Advanced liver fibrosis is common in patients with type 2 diabetes followed in the outpatient setting: the need for systematic screening. Diabetes Care. (2021) 44(2):399–406. doi: 10.2337/dc20-1997 - DOI - PMC - PubMed

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