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. 2024 Dec 5;14(12):8320-8330.
doi: 10.21037/qims-23-1603. Epub 2024 Oct 24.

Evaluation of neostriatum changes in Crohn's disease: a multimodal brain magnetic resonance imaging study

Pengyu Li #  1   2 , Fenrong Chen #  3 , Duoli Chen  1   2 , Zi Wei  1   2 , Dingxin Nie  1   2 , Chengxiang Liu  1   2 , Peng Liu  1   2
Affiliations

Evaluation of neostriatum changes in Crohn's disease: a multimodal brain magnetic resonance imaging study

Pengyu Li et al. Quant Imaging Med Surg. .

Abstract

Background: Abnormalities of neostriatum have been reported to be implicated in Crohn's disease (CD). However, there are few systematic explorations. We aim to explore the changes that occur in the structure and function of the neostriatum and whether these changes are related to the clinical characteristics of CD.

Methods: In this cross-sectional and prospective study, we enrolled 34 CD patients and 31 healthy controls (HCs) for analysis. We performed voxel-based morphometry (VBM) and seed-based functional connectivity (FC) to evaluate the structural and functional changes in the neostriatum. Correlation analysis was used to evaluate the possible relationships between clinical characteristics and neuroimaging findings.

Results: CD patients had significantly increased gray matter volume (GMV) in the bilateral putamen compared with HCs. The results showed that CD patients had significantly decreased FC related to the putamen-calcarine cortex, putamen-fusiform gyrus, putamen-inferior temporal cortex (ITC), putamen-parahippocampus, and increased FC associated with the putamen-cuneus/precuneus. Moreover, CD patients showed a positive correlation between the GMV in the left putamen and illness duration (r=0.42, P=0.013).

Conclusions: Our study indicated that CD patients had increased GMV and abnormal FC related to the putamen. The structural and functional differences could reflect that neostriatum may be linked with alterations of aberrant patterns of the default mode network (DMN) and visual processing area.

Keywords: Crohn’s disease (CD); functional connectivity (FC); magnetic resonance imaging (MRI); neostriatum; voxel-based morphometry (VBM).

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Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://qims.amegroups.com/article/view/10.21037/qims-23-1603/coif). The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
The GMV differences between CD patients and HCs in the bilateral neostriatum: (A) the region of the caudate nucleus and putamen bilaterally; (B) significant differences in the bilateral putamen between CD patients and HCs (covariates were age, sex and TIV); and (C) significant differences in the bilateral putamen between CD patients and HCs (covariates were age, sex, TIV and HADS). R, right; TIV, total intracranial volume; HADS, Hospital Anxiety and Depression Scale; GMV, gray matter volume; CD, Crohn’s disease; HCs, healthy controls.
Figure 2
Figure 2
Comparison of GMV in CD patients and HCs at peak coordinates. Box represents the quartile range of data. The upper boundary of the box is Q3, the lower boundary is Q1, and the median inside the box is represented by a line. Whisker: a straight line extending from the upper and lower ends of the box to represent the maximum and minimum values of the data. ***, P value <0.001. CD, Crohn’s disease; HCs, healthy controls; GMV, gray matter volume.
Figure 3
Figure 3
Brain regions with significant differences in FC between CD patients and HCs of (A) the left putamen and (B) the right putamen. Circles: the activation region where the ROIs are located. R, right; HADS, Hospital Anxiety and Depression Scale; ITC, inferior temporal cortex; CD, Crohn’s disease; HCs, healthy controls; FC, functional connectivity; ROIs, regions of interest.
Figure 4
Figure 4
Correlation between the illness duration and GMV in the left and right putamen. GMV, gray matter volume.
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