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. 2025 Jan 9;188(1):104-120.e18.
doi: 10.1016/j.cell.2024.11.014. Epub 2024 Dec 18.

The auditory midbrain mediates tactile vibration sensing

Erica L Huey  1 , Josef Turecek  1 , Michelle M Delisle  1 , Ofer Mazor  2 , Gabriel E Romero  2 , Malvika Dua  1 , Zoe K Sarafis  1 , Alexis Hobble  1 , Kevin T Booth  2 , Lisa V Goodrich  2 , David P Corey  2 , David D Ginty  3
Affiliations

The auditory midbrain mediates tactile vibration sensing

Erica L Huey et al. Cell. .

Abstract

Vibrations are ubiquitous in nature, shaping behavior across the animal kingdom. For mammals, mechanical vibrations acting on the body are detected by mechanoreceptors of the skin and deep tissues and processed by the somatosensory system, while sound waves traveling through air are captured by the cochlea and encoded in the auditory system. Here, we report that mechanical vibrations detected by the body's Pacinian corpuscle neurons, which are distinguished by their ability to entrain to high-frequency (40-1,000 Hz) environmental vibrations, are prominently encoded by neurons in the lateral cortex of the inferior colliculus (LCIC) of the midbrain. Remarkably, most LCIC neurons receive convergent Pacinian and auditory input and respond more strongly to coincident tactile-auditory stimulation than to either modality alone. Moreover, the LCIC is required for behavioral responses to high-frequency mechanical vibrations. Thus, environmental vibrations captured by Pacinian corpuscles are encoded in the auditory midbrain to mediate behavior.

Keywords: in vivo physiology; mechanotransduction; multi-sensory integration; somatosensory neurons; vibration.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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References

    1. Cividini S, Sfenthourakis S, and Montesanto G (2019). Are terrestrial isopods able to use stridulation and vibrational communication as forms of intra and interspecific signaling and defense strategies as insects do? A preliminary study in Armadillo officinalis. Naturwissenschaften 107, 4. 10.1007/s00114-019-1656-3. - DOI - PubMed
    1. Narins PM, Reichman OJ, Jarvis JU, and Lewis ER (1992). Seismic signal transmission between burrows of the Cape mole-rat, Georychus capensis. J Comp Physiol A 170, 13–21. 10.1007/BF00190397. - DOI - PubMed
    1. Nevo E, Heth G, and Pratt H (1991). Seismic communication in a blind subterranean mammal: a major somatosensory mechanism in adaptive evolution underground. Proc Natl Acad Sci U S A 88, 1256–1260. 10.1073/pnas.88.4.1256. - DOI - PMC - PubMed
    1. O’Connell-Rodwell CE (2007). Keeping an “ear” to the ground: seismic communication in elephants. Physiology (Bethesda) 22, 287–294. 10.1152/physiol.00008.2007. - DOI - PubMed
    1. Virant-Doberlet M, Stritih-Peljhan N, Zunic-Kosi A, and Polajnar J (2023). Functional Diversity of Vibrational Signaling Systems in Insects. Annu Rev Entomol 68, 191–210. 10.1146/annurev-ento-120220-095459. - DOI - PubMed

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