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Review
. 2025 Jun;36(6):507-510.
doi: 10.1016/j.tem.2024.11.015. Epub 2024 Dec 18.

More than carriers, orosomucoids are key metabolic modulators

Mi Jeong Heo  1 , Inyoung Cheon  2 , Kang Ho Kim  3
Affiliations
Review

More than carriers, orosomucoids are key metabolic modulators

Mi Jeong Heo et al. Trends Endocrinol Metab. 2025 Jun.

Abstract

Orosomucoids (ORMs) have historically been considered as carriers involved in drug and lipid delivery. However, recent studies indicate ORM2 as a hepatokine involved in metabolic regulation. Here, we highlight the functions of ORM2 in controlling metabolic health and disease, focusing on its newly discovered regulatory mechanisms.

Keywords: diabetes; hepatic steatosis; hepatokine; inflammation; obesity; orosomucoid 2.

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Conflict of interest statement

Declaration of interests All authors declare no conflicts of interest.

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