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Review
. 2024 Dec 19;24(1):267.
doi: 10.1186/s12894-024-01665-8.

Benign phyllodes tumor of the distal end of the ureter: an extremely rare case and literature review

Li-Xia Xu  1   2 , Peng-Tao Song  3   4 , Jin-Liang Pin  3   4
Affiliations
Review

Benign phyllodes tumor of the distal end of the ureter: an extremely rare case and literature review

Li-Xia Xu et al. BMC Urol. .

Abstract

A phyllodes tumor (PT) is a biphasic fibroepithelial lesion that is most commonly found in breast tissue, whereas it is uncommon in ureter tissue. Only one case has been documented so far. There are some similarities in histology and clinical characteristics between this type of tumor and PT of the female breast: the lesions can be surgically removed, but some recur locally and invade directly into the breast. This case of a primary PT of the ureter is useful for pathologists and clinicians.

Keywords: Case report; Fibroepithelial lesion; Phyllodes tumor; Ureter.

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: Ethics approval was obtained from the Institutional Research Ethics Board of Huzhou central Hospital. Consent was obtained from the patient in writing. Consent for publication: All the authors agree with this case for publication. Written informed consent was obtained from the patient for publication of this case report. Clinical trial number: Not applicable. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
US and Computed tomography (CT) images of a ureteral tumor. (A) On color ultrasonography of both kidneys, ureters, and bladders, the right kidney was found to have atrophy, the right kidney was found to have calculi, and the right ureter was occupied by fluid. (B) Enhanced arterial phase abdominal oblique sagittal reconstruction. (C) CT plain scan. (D) Enhanced CT arterial phase (E) Enhanced CT venous phase. the right ureter was thickened, the middle and lower ureters were unevenly enhanced after enhancement
Fig. 2
Fig. 2
Results of the histological analysis of the resected tumor. (A-B) Hematoxylin and eosin-stained sections showing a polypoid and lobulated ureteral tumor. (C-D) The stroma appeared spindle shaped and stellate, with no apparent cytological atypia or mitoses (x400). (E-F) There was a relatively clear border around the perimeter of the lesion (×100)
Fig. 3
Fig. 3
The immunohistochemistry of a resected tumor was observed. (A) Positive Vim staining was observed in the stromal component (×100). (B) Negative staining of SMA was observed in the stromal component (×100). (C) Positive CK staining was observed in the urothelia component (×100). (D) Low positive staining of CK5/6 was observed in the urothelium component (×100). (E) Positive CK7 staining was observed in the urothelium component (×100). (F) Positive CK20 staining was observed in the urothelium component (×100). (G) Scattered positive staining for CD117 was observed in the stromal component (×100). (H) Scattered positive staining of CD99 was observed in the urothelium component (×100). (I) Partial positive staining of Bcl-2 was observed in the urothelium component (×100). (K) Positive staining of GATA-3 was observed in the urothelium component (×100). (L) Negative staining of EMA was observed in the urothelia component (×100). (M) Wild-type expression of P53 in the urothelium component (×100). (N) Positive staining of EMA was observed in the urothelia component (×100). (O) Ki-67 staining revealed a 3% proliferation index for urothelial and stromal cells (×200)
See this image and copyright information in PMC

References

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