Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Dec;33(12):e70046.
doi: 10.1002/pon.70046.

Predictive Value of Individual Behavioral Risk Factors for New Mood-Related Psychiatric Disorder After Diagnosis of Cancer

Seiichi Villalona  1   2 , Carlos Chavez Perez  1 , E Paul Wileyto  3 , Samuel Takvorian  4   5 , Peter Gabriel  5 , Abigail Doucette  6 , Daniel Blumenthal  7 , Robert Schnoll  5   7
Affiliations

Predictive Value of Individual Behavioral Risk Factors for New Mood-Related Psychiatric Disorder After Diagnosis of Cancer

Seiichi Villalona et al. Psychooncology. 2024 Dec.

Abstract

Objective: The diagnosis of a mood-related psychiatric disorder (MRPD) among patients with cancer has been associated with decreased quality of life and lower cancer survival. This study aimed to understand the risk of a new MRPD after cancer diagnosis by individual risk behaviors, with a specific focus on tobacco use and the presence of a human papillomavirus (HPV)-associated cancer.

Methods: Single-center retrospective cohort study of 11,712 patients diagnosed with cancer between 2009 and 2020. We identified predictors of a new MRPD after cancer diagnosis using a time-to-event analysis and Cox proportional hazards model including demographics, disease characteristics, and tobacco use and HPV-associated tumors.

Results: Univariate analyses revealed lower hazard ratios (HRs) of a new MRPD among individuals that identified as Asian/Pacific Islanders and among the older age groups (> 51 years). Univariate analyses additionally demonstrated higher HRs of MRPD among females; sexual minorities; former and current smokers; individuals with HPV-associated cancers; and individuals diagnosed at later stages. These relationships were observed in the multivariate model when adjusting for covariates. Shorter time-to-MRPD was observed when stratifying by individual behavioral risk factors, with active smokers and individuals with an HPV-associated cancer being at the highest risk.

Conclusions: Individual behavioral risk factors increase risk of new MRPD after being diagnosed with cancer. These findings build on past studies by linking tobacco use and HPV-associated cancers with MRPD risk in oncology and can be used to identify patients at risk of developing new MRPDs post-cancer diagnosis and engaging them in treatment.

Keywords: HPV‐associated cancers; Psycho‐oncology; anxiety; depression; tobacco use.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Kaplan–Meier estimate of time to mood related psychiatric disorder diagnosis post‐cancer diagnosis. HPVa = Human papillomavirus associated.
See this image and copyright information in PMC

References

    1. Mitchell A. J., Chan M., Bhatti H., et al., “Prevalence of Depression, Anxiety, and Adjustment Disorder in Oncological, Haematological, and Palliative‐Care Settings: A Meta‐Analysis of 94 Interview‐Based Studies,” Lancet Oncology 12, no. 2 (2011): 160–174, 10.1016/s1470-2045(11)70002-x. - DOI - PubMed
    1. Pitman A., Suleman S., Hyde N., and Hodgkiss A., “Depression and Anxiety in Patients With Cancer,” BMJ 361 (2018): k1415, 10.1136/bmj.k1415. - DOI - PubMed
    1. Walker J., Hansen C. H., Martin P., et al., “Prevalence, Associations, and Adequacy of Treatment of Major Depression in Patients With Cancer: A Cross‐Sectional Analysis of Routinely Collected Clinical Data,” Lancet Psychiatry 1, no. 5 (2014): 343–350, 10.1016/s2215-0366(14)70313-x. - DOI - PubMed
    1. Pinquart M. and Duberstein P., “Depression and Cancer Mortality: A Meta‐Analysis,” Psychological Medicine 40, no. 11 (2010): 1797–1810, 10.1017/s0033291709992285. - DOI - PMC - PubMed
    1. Satin J. R., Linden W., and Phillips M. J., “Depression as a Predictor of Disease Progression and Mortality in Cancer Patients: A Meta‐analysis,” Cancer 115, no. 22 (2009): 5349–5361, 10.1002/cncr.24561. - DOI - PubMed

LinkOut - more resources