Noninvasive detection of twin zygosity using genome-wide linkage disequilibrium information
- PMID: 39702938
- PMCID: PMC11659192
- DOI: 10.1002/ctm2.70130
Noninvasive detection of twin zygosity using genome-wide linkage disequilibrium information
Abstract
Dear Editor, in this study, we propose a novel linkage disequilibrium information-based noninvasive zygosity (LDNZ) assessment method in twin pregnancies. It combines fetus-specific allele frequency analysis with LD block to reduce the number of required single nucleotide polymorphism markers and experiment costs. LDNZ method offers a noninvasive, accurate, and cost-effective solution for zygosity assessment, addressing the need for precise obstetric care in twin pregnancies.
© 2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.
Conflict of interest statement
Chao Yuan and Di Wu are employed by Celula (China) Medical Technology Co., Ltd. The remaining authors declare no conflict of interest.
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