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. 2024 Dec 5:15:1471736.
doi: 10.3389/fneur.2024.1471736. eCollection 2024.

Association between herpes zoster and Parkinson's disease and dementia: a systematic review and meta-analysis

Yanfeng Zhang #  1 , Weiping Liu  1 , Yang Xu #  2   3
Affiliations

Association between herpes zoster and Parkinson's disease and dementia: a systematic review and meta-analysis

Yanfeng Zhang et al. Front Neurol. .

Abstract

Objectives: This meta-analysis investigated the relationship between herpes zoster and the risk of dementia or Parkinson's disease by analyzing published clinical studies.

Methods: We systematically searched PubMed, Cochrane, Embase, and Web of Science Core Collection databases on April 25, 2024. Hazard ratios (HR) were used for statistical analyses. Random-effects models were applied, and heterogeneity was assessed using the I2 statistic.

Results: Herpes zoster was associated with a non-significant trend toward increased dementia risk (HR = 1.11, 95% CI 0.99-1.24, p = 0.07) but significantly increased Parkinson's disease risk (HR = 1.15, 95% CI 1.03-1.30, p = 0.02). Subgroup analyses revealed that herpes zoster significantly elevated the risk of the prospective study subgroup (HR = 1.08, 95% CI 1.02-1.13, p = 0.004) and vascular dementia subgroup (HR = 1.17, 95% CI 1.00-1.37, p = 0.05). Significant heterogeneity was observed for both outcomes (dementia: I 2 = 98%, p < 0.00001; Parkinson's disease: I 2 = 94%, p < 0.00001).

Conclusion: Herpes zoster raises the risk of Parkinson's disease and vascular dementia, with a potential causal link to dementia. Early vaccination against herpes zoster is recommended over post-infection antiviral treatment to mitigate risks.

Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/ and our registration number is CRD42024555620.

Keywords: Parkinson’s disease; dementia; herpes zoster; meta-analysis; systematic review; vascular dementia.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of literature screening process.
Figure 2
Figure 2
Forest plot of overall analysis results. (A) Forest plots for overall dementia-related analyses; (B) Forest plots for overall analyses related to Parkinson’s disease.
Figure 3
Figure 3
Sensitivity analysis results. (A) Overall analysis of herpes zoster and dementia and 95% CI calculations from Stata software. (B) Overall analysis of herpes zoster and Parkinson’s disease and 95% CI calculations from Stata software.
See this image and copyright information in PMC

References

    1. Coelho M, Ferreira JJ. Late-stage Parkinson disease. Nat Rev Neurol. (2012) 8:435–42. doi: 10.1038/nrneurol.2012.126 - DOI - PubMed
    1. Fernandez HH, Galvez-Jimenez N, Fernandez HH. Nonmotor complications of Parkinson disease. Cleve Clin J Med. (2012) 79:S14–8. doi: 10.3949/ccjm.79.s2a.03 - DOI - PubMed
    1. Noyce AJ, Bestwick JP, Silveira-Moriyama L, Hawkes CH, Giovannoni G, Lees AJ, et al. Meta-analysis of early nonmotor features and risk factors for Parkinson disease. Ann Neurol. (2012) 72:893–901. doi: 10.1002/ana.23687, PMID: - DOI - PMC - PubMed
    1. Matthews KA, Xu W, Gaglioti AH, Holt JB, Croft JB, Mack D, et al. Racial and ethnic estimates of Alzheimer's disease and related dementias in the United States (2015–2060) in adults aged ≥65 years. Alzheimers Dement. (2019) 15:17–24. doi: 10.1016/j.jalz.2018.06.3063, PMID: - DOI - PMC - PubMed
    1. Prince M, Wimo A, Guerchet M, Ali GC, Wu Y-T, Prina M, et al. World Alzheimer report 2015: The global impact of dementia. London: Alzheimer’s Disease International; (2015).

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