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. 2024 Jan;23(1):38-43.

Mortality Rate and Its Contributing Factors in Post-Surgical and Medical Patients with AKI Underwent CRRT

Fatemeh Yassari  1 , Batoul Khoundabi  2   3 , Farin Rashid Farokhi  4 , Rajesh Chandra Mishra  5 , Ahsina Jahan Lopa  6 , Seyed MohammadReza Hashemian  1
Affiliations

Mortality Rate and Its Contributing Factors in Post-Surgical and Medical Patients with AKI Underwent CRRT

Fatemeh Yassari et al. Tanaffos. 2024 Jan.

Abstract

Background: Acute kidney injury (AKI) requires continuous renal replacement therapy (CRRT), which is one of the most important problems in medical and surgical patients. Therefore, it is very important to identify the influencing factors to reduce the dimensions of the problem. This study was conducted to investigate the mortality rate in medical and surgical patients with AKI requiring CRRT treatment.

Materials and methods: In this observational study, which was conducted as a cross- sectional analytical study, 100 patients with AKI requiring CRRT treatment, including medical and surgical patients, were selected from 2018 to 2021 at Masih Daneshvari Hospital. The mortality rate was estimated. Also, the effective factors were investigated and compared between the dead and surviving patients.

Results: 85 cases (85%) of the patients died. Most underlying and demographic variables had no statistically significant difference between the dead and surviving patients (P>0.05). However, in the cases of primary calcium (P=0.001), primary leukocyte (P=0.037), bicarbonate during hospitalization (P=0.025), bicarbonate during AKI (P=0.028), magnesium during hospitalization (P=0.038), and magnesium at the end of CRRT (P=0.019), the differences were statistically significant.

Conclusion: In conclusion, mortality is observed in 5 out of 6 patients with acute kidney failure who need CRRT treatment, which is related to risk factors such as bicarbonate, magnesium, leukocyte, and calcium levels. Therefore, multifaceted planning is needed to reduce its dimensions to improve the prognosis of this group of patients.

Keywords: Acute kidney injury (AKI); Continuous renal replacement therapy (CRRT); Mortality.

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Conflict of interest statement

Conflict of Interest There is no conflict of interest.

References

    1. Bonventre JV. Pathophysiology of AKI: injury and normal and abnormal repair. Contrib Nephrol 2010;1659–17 - PubMed
    1. Chertow GM, Burdick E, Honour M, Bonventre JV, Bates DW. Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J Am Soc Nephrol 2005;16(11):3365–70. - PubMed
    1. Devarajan P. Update on mechanisms of ischemic acute kidney injury. J Am Soc Nephrol 2006;17(6):1503–20. - PubMed
    1. Wald R, Quinn RR, Luo J, Li P, Scales DC, Mamdani MM, Ray JG, University of Toronto Acute Kidney Injury Research Group . Chronic dialysis and death among survivors of acute kidney injury requiring dialysis. JAMA 2009;302(11):1179–85. - PubMed
    1. Waikar SS, Bonventre JV. Creatinine kinetics and the definition of acute kidney injury. J Am Soc Nephrol 2009;20(3):672–9. - PMC - PubMed

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