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Meta-Analysis
. 2024 Dec 16:12:e18652.
doi: 10.7717/peerj.18652. eCollection 2024.

Comparative effectiveness and safety of Angio-Seal and StarClose vascular closure devices: a systematic review and meta-analysis

Kun Lai #  1 , Jingquan Chen  1 , Qiang Tan  1 , Lan Luo #  1
Affiliations
Meta-Analysis

Comparative effectiveness and safety of Angio-Seal and StarClose vascular closure devices: a systematic review and meta-analysis

Kun Lai et al. PeerJ. .

Abstract

Objective: This systematic review and meta-analysis aims to evaluate the effectiveness and safety of Angio-Seal and StarClose vascular closure devices (VCDs) in achieving hemostasis after interventional surgery.

Methods: Randomized controlled trials (RCTs) and observational studies comparing Angio-Seal and StarClose were identified through systematic searches. Data on vascular closure success rate, complication rates, hematoma formation, pseudoaneurysm, arterial occlusion, and surgical intervention were extracted and pooled using a random effects model.

Results: Nine studies met the inclusion criteria, total 5,466 patients. The meta-analysis revealed a slight, statistically significant difference in the success rate of vascular closure in favor of Angio-Seal (risk ratio (RR) 1.05, 95% confidence interval (CI) [1.00-1.09], p = 0.03). No significant difference was found in the overall complication rate, hematoma formation, pseudoaneurysm, arterial occlusion, or surgical intervention.

Conclusions: Angio-Seal demonstrated a slightly higher success rate in vessel closure compared to StarClose. Both devices had a comparable safety profile with no significant differences in major complications.

Keywords: Angio-seal; Complications; Hemostasis; Meta-analysis; StarClose; Systematic review; Vascular closure devices.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1. PRISMA flowchart.
Figure 2
Figure 2. Success rate of vascular closure (Elmasri et al., 2017; Rastan et al., 2008; Ratnam et al., 2007; Deuling et al., 2008; Veasey et al., 2008).
Figure 3
Figure 3. Complication (Elmasri et al., 2017; Rastan et al., 2008; Ratnam et al., 2007; Engelbert et al., 2010; Lucatelli et al., 2017; Gonen, Hakyemez & Erdogan, 2021).
Figure 4
Figure 4. Subgroup complication (Rastan et al., 2008; Ratnam et al., 2007; Deuling et al., 2008; Lucatelli et al., 2017; Gonen, Hakyemez & Erdogan, 2021).
Figure 5
Figure 5. Surgical intervention requirement (Ratnam et al., 2007; Lucatelli et al., 2017).
See this image and copyright information in PMC

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