The Fifth Annual Symposium of the Midwest Aging Consortium

Brenda F Reader¹, Lorena Rosas², Bailey Anna Knopf^{3

4}, Yang Liu^{3

4}, Diego Alzate-Correa⁵, Ajay Bhat⁶, Anna Carey⁷, Ana Maria Cuervo⁸, Sanjana Dayal⁹, Rafael S Demarco¹⁰, Christian J Elliehausen^{11

12}, Davis A Englund^{13

14}, Haylee L Hamilton¹¹, Matthew Johnston¹⁵, Ping Kang¹⁶, Adam R Konopka^{11

12}, Noah Lepola¹⁷, Carolyn J Presley¹⁸, Marissa J Schafer^{13

19}, Joan Serrano²⁰, Benjamin D Singer^{21

22}, Min-Ae Song²³, Kristin I Stanford²⁴, Jackson Taylor²⁵, Wei Wei²⁶, Chung-Yang Yeh^{3

4}, Lei Zhang²⁷, Lei Zhang⁷, Rozalyn M Anderson^{12

28}, Hua Bai¹⁶, Paul D Robbins⁷, Dudley W Lamming^{3

4}, Maria M Mihaylova^{20

29}, Mauricio Rojas², Ana L Mora²

Affiliations

¹ Division of Transplantation Surgery, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
² Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA.
³ Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.
⁴ William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin, USA.
⁵ Department of Biomedical Engineering, The Ohio State University, Columbus, Ohio, USA.
⁶ Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA.
⁷ Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA.
⁸ Department of Developmental and Molecular Biology, Institute for Aging Research, Albert Einstein College of Medicine, Bronx, New York, USA.
⁹ Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
¹⁰ Department of Biology, University of Louisville, Louisville, Kentucky, USA.
¹¹ Division of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.
¹² Geriatric Research, Education, and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin, USA.
¹³ Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.
¹⁴ Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, Minnesota, USA.
¹⁵ Biomedical Sciences Department, University of North Dakota, Grand Forks, North Dakota, USA.
¹⁶ Department of Genetics, Development, and Cell Biology, Iowa State University, Ames, Iowa, USA.
¹⁷ Departments of Molecular Genetics, Cancer Biology, and Genetics, The Ohio State University, Columbus, Ohio, USA.
¹⁸ Division of Medical Oncology, Department of Medicine, The Ohio State University, Columbus, Ohio, USA.
¹⁹ Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
²⁰ Department of Biological Chemistry and Pharmacology, College of Medicine, The Ohio State University, Columbus, Ohio, USA.
²¹ Division of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
²² Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
²³ Division of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, Ohio, USA.
²⁴ Division of General and Gastrointestinal Surgery, Department of Surgery, The Ohio State University College of Medicine, Columbus, Ohio, USA.
²⁵ Center for Gene Regulation in Health and Disease, Department of Biological, Geological, and Environmental Sciences, Cleveland State University, Cleveland, Ohio, USA.
²⁶ Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.
²⁷ Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, Minnesota, USA.
²⁸ Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
²⁹ The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.

PMID: 39704343
PMCID: PMC11772560 (available on 2025-12-20)
DOI: 10.1093/gerona/glae296

The Fifth Annual Symposium of the Midwest Aging Consortium

Brenda F Reader et al. J Gerontol A Biol Sci Med Sci. 2025.

. 2025 Jan 16;80(2):glae296.

doi: 10.1093/gerona/glae296.

Authors

Affiliations

¹ Division of Transplantation Surgery, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
² Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA.
³ Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.
⁴ William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin, USA.
⁵ Department of Biomedical Engineering, The Ohio State University, Columbus, Ohio, USA.
⁶ Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA.
⁷ Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA.
⁸ Department of Developmental and Molecular Biology, Institute for Aging Research, Albert Einstein College of Medicine, Bronx, New York, USA.
⁹ Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
¹⁰ Department of Biology, University of Louisville, Louisville, Kentucky, USA.
¹¹ Division of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.
¹² Geriatric Research, Education, and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin, USA.
¹³ Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.
¹⁴ Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, Minnesota, USA.
¹⁵ Biomedical Sciences Department, University of North Dakota, Grand Forks, North Dakota, USA.
¹⁶ Department of Genetics, Development, and Cell Biology, Iowa State University, Ames, Iowa, USA.
¹⁷ Departments of Molecular Genetics, Cancer Biology, and Genetics, The Ohio State University, Columbus, Ohio, USA.
¹⁸ Division of Medical Oncology, Department of Medicine, The Ohio State University, Columbus, Ohio, USA.
¹⁹ Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
²⁰ Department of Biological Chemistry and Pharmacology, College of Medicine, The Ohio State University, Columbus, Ohio, USA.
²¹ Division of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
²² Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
²³ Division of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, Ohio, USA.
²⁴ Division of General and Gastrointestinal Surgery, Department of Surgery, The Ohio State University College of Medicine, Columbus, Ohio, USA.
²⁵ Center for Gene Regulation in Health and Disease, Department of Biological, Geological, and Environmental Sciences, Cleveland State University, Cleveland, Ohio, USA.
²⁶ Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.
²⁷ Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, Minnesota, USA.
²⁸ Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
²⁹ The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.

PMID: 39704343
PMCID: PMC11772560 (available on 2025-12-20)
DOI: 10.1093/gerona/glae296

Abstract

As the healthcare burden caused by an increasingly aging population rapidly rises, a pressing need exists for innovative geroscience research that can elucidate aging mechanisms and precipitate the development of therapeutic interventions to support healthy aging. The Fifth Annual Midwest Aging Consortium Aging Research symposium, held from April 28 to 30, 2024, was hosted by The Ohio State University in Columbus, Ohio, and featured presentations from investigators across the Midwestern United States. This report summarizes the research presented at the symposium, whose topics included cellular senescence and the aging brain, metabolism and metabolic interventions, nutrition, redox mechanisms and biomarkers, and stress mechanisms. Abstract presentations and short talks highlighted early-stage and young investigators, whereas 2 keynote presentations anchored the symposium. Overall, this symposium showed the robustness of aging research in the Midwest and underscored the advantages of a collaborative approach to geroscience research.

Keywords: Biomarkers; Cellular senescence; Geroscience; Metabolism; Nutrition; Stress.

© The Author(s) 2024. Published by Oxford University Press on behalf of the Gerontological Society of America. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.

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Conflict of interest statement

D.W.L. has received funding from, and is a scientific advisory board member of, Aeovian Pharmaceuticals, which seeks to develop novel, selective mTOR inhibitors for the treatment of various diseases. B.D.S. holds US patent 10,905,706, “Compositions and methods to accelerate resolution of acute lung inflammation,” and serves on the scientific advisory board of Zoe Biosciences, in which he holds stock options. L.Z. is a co-founder and shareholder of SingulOmics Corp. The other authors declare no conflict.

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The Fifth Annual Symposium of the Midwest Aging Consortium

Affiliations

The Fifth Annual Symposium of the Midwest Aging Consortium

Authors

Affiliations

Abstract

Conflict of interest statement

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical

Research Materials

Miscellaneous