Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2025 Mar;48(3):1225-1227.
doi: 10.1038/s41440-024-02063-1. Epub 2024 Dec 20.

Body fluid management as a treatment for obstructive sleep apnea: a new possibility for sodium-glucose cotransporter 2 inhibitors

Hiromitsu Sekizuka  1
Affiliations
Editorial

Body fluid management as a treatment for obstructive sleep apnea: a new possibility for sodium-glucose cotransporter 2 inhibitors

Hiromitsu Sekizuka. Hypertens Res. 2025 Mar.
No abstract available

Keywords: Fluid shift; Heart failure; Novel therapy; Sleep-disordered breathing; Tofogliflozin.

PubMed Disclaimer

Conflict of interest statement

Compliance with ethical standards. Conflict of interest: The authors declare no competing interests.

Comment on

References

    1. Ishiwata S., Kasai T., Sato A., Suda S, Matsumoto H. et al. Tofogliflozin reduces sleep apnea severity in patients with type 2 diabetes mellitus and heart failure: a prospective study. Hypertens Res. 2025;48:388–97.
    1. Yumino D, Redolfi S, Ruttanaumpawan P, Su MC, Smith S, Newton GE, et al. Nocturnal rostral fluid shift: a unifying concept for the pathogenesis of obstructive and central sleep apnea in men with heart failure. Circulation. 2010;121:1598–605. - DOI - PubMed
    1. Ding N, Lin W, Zhang XL, Ding WX, Gu B, Ni BQ, et al. Overnight fluid shifts in subjects with and without obstructive sleep apnea. J Thorac Dis. 2014;6:1736–41. - PubMed - PMC
    1. Redolfi S, Yumino D, Ruttanaumpawan P, Yau B, Su MC, Lam J, et al. Relationship between overnight rostral fluid shift and obstructive sleep Apnea in nonobese men. Am J Respir Crit Care Med. 2009;179:241–6. - DOI - PubMed
    1. Silva BC, Santos RSS, Drager LF, Coelho FM, Elias RM. Impact of compression stockings vs. continuous positive airway pressure on overnight fluid shift and obstructive sleep apnea among patients on hemodialysis. Front Med. 2017;4:57. - DOI