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Multicenter Study
. 2024 Dec 20;41(1):38.
doi: 10.1007/s00383-024-05935-2.

Short-term postoperative complications in preterm neonates with surgical necrotizing enterocolitis: a multicenter retrospective cohort study

Adinda G H Pijpers #  1   2   3 , Ceren Imren #  4 , Otis C van Varsseveld  5 , Jan B F Hulscher  5 , Elisabeth M W Kooi  6 , Chris H P van den Akker  7   8   9 , Joost van Schuppen  10 , Jos W R Twisk  11 , Joep P M Derikx  12   7   8 , Marijn J Vermeulen  13 , Claudia M G Keyzer-Dekker  4
Affiliations
Multicenter Study

Short-term postoperative complications in preterm neonates with surgical necrotizing enterocolitis: a multicenter retrospective cohort study

Adinda G H Pijpers et al. Pediatr Surg Int. .

Abstract

Background: Over half of preterm neonates with necrotizing enterocolitis (NEC) require surgery, making it essential to understand short-term postoperative outcomes and complication rates. Therefore, this study aimed to provide an overview of 30-day postoperative complications for NEC. Secondary, risk factors for minor and major short-term postoperative complications were identified.

Methods: This retrospective study included all preterm infants (GA < 35w) surgically treated for NEC from 2008 to 2022. Postoperative complications were scored following the Clavien-Madadi classification. Risk factors were analyzed using multivariable logistic regression analysis.

Results: In this cohort of 326 patients, 204 received a stoma, 80 had a primary anastomosis, and 32 had both. Postoperative mortality was 19.0%. In total, 186 patients experienced 238 complications (57.1%), including 118 (63.4%) major and 68 (36.6%) minor complications. Most common complications were sepsis (19.4%), stoma-related (13.3%), and wound dehiscence (11.3%). Cardiovascular support between NEC diagnosis and surgery was a significant risk factor for major complications (OR: 1.92, 95%-CI 1.19-3.08, p = 0.007) and stoma creation for minor complications (OR: 6.73, 95%-CI 2.05-22.05, p = 0.002).

Conclusion: This study showed a postoperative complication rate of 57.1%. We found cardiovascular support between NEC diagnosis and surgery as risk factor for major complications and stoma creation as risk factor for minor complications. These findings provide valuable insights for improving parental counseling on NEC outcomes.

Level of evidence: II.

Keywords: Clavien–Madadi; Enterostomy; Infants; Primary anastomosis; Risk factors.

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Conflict of interest statement

Declarations. Conflict of interest: The authors declare no competing interests.

References

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