Association between gut microbiota and ultra-processed foods consumption among the patients with type 2 diabetes: a cross-sectional study

Takahiro Ichikawa¹, Yoshitaka Hashimoto^{1

2}, Yusuke Igarashi¹, Sayaka Kawai¹, Ayumi Kaji¹, Ryosuke Sakai¹, Takafumi Osaka^{1

3}, Ryo Inoue^{4

5}, Saori Kashiwagi^{6

7}, Katsura Mizushima⁶, Kazuhiko Uchiyama⁶, Tomohisa Takagi^{6

8}, Yuji Naito⁹, Masahide Hamaguchi¹⁰, Michiaki Fukui¹

Affiliations

¹ Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-Cho, Kawaramachi-Hirokoji, Kamigyo-Ku, Kyoto, 602-8566, Japan.
² Department of Diabetes and Endocrinology, Matsushita Memorial Hospital, 5-55 Sotojima-Cho, Moriguchi, 570-8540, Japan.
³ Department of Endocrinology and Diabetology, Ayabe Municipal Hospital, Ayabe, 623-0011, Japan.
⁴ Laboratory of Animal Science, Kyoto Prefectural University, Kyoto, 606-8522, Japan.
⁵ Laboratory of Animal Science, Setsunan University, Hirakata, 573-0101, Japan.
⁶ Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-Cho, Kawaramachi-Hirokoji, Kamigyo-Ku, Kyoto, 602-8566, Japan.
⁷ Division of Gastroenterology and Hepatology, Department of Medicine, Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
⁸ Department for Medical Innovation and Translational Medical Science, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-Cho, Kawaramachi-Hirokoji, Kamigyo-Ku, Kyoto, 602-8566, Japan.
⁹ Department of Human Immunology and Nutrition Science, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo-Ku, Kyoto, Japan.
¹⁰ Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-Cho, Kawaramachi-Hirokoji, Kamigyo-Ku, Kyoto, 602-8566, Japan. mhama@koto.kpu-m.ac.jp.

PMID: 39707434
PMCID: PMC11662526
DOI: 10.1186/s12986-024-00884-y

Association between gut microbiota and ultra-processed foods consumption among the patients with type 2 diabetes: a cross-sectional study

Takahiro Ichikawa et al. Nutr Metab (Lond). 2024.

. 2024 Dec 20;21(1):110.

doi: 10.1186/s12986-024-00884-y.

Authors

Affiliations

¹ Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-Cho, Kawaramachi-Hirokoji, Kamigyo-Ku, Kyoto, 602-8566, Japan.
² Department of Diabetes and Endocrinology, Matsushita Memorial Hospital, 5-55 Sotojima-Cho, Moriguchi, 570-8540, Japan.
³ Department of Endocrinology and Diabetology, Ayabe Municipal Hospital, Ayabe, 623-0011, Japan.
⁴ Laboratory of Animal Science, Kyoto Prefectural University, Kyoto, 606-8522, Japan.
⁵ Laboratory of Animal Science, Setsunan University, Hirakata, 573-0101, Japan.
⁶ Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-Cho, Kawaramachi-Hirokoji, Kamigyo-Ku, Kyoto, 602-8566, Japan.
⁷ Division of Gastroenterology and Hepatology, Department of Medicine, Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
⁸ Department for Medical Innovation and Translational Medical Science, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-Cho, Kawaramachi-Hirokoji, Kamigyo-Ku, Kyoto, 602-8566, Japan.
⁹ Department of Human Immunology and Nutrition Science, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo-Ku, Kyoto, Japan.
¹⁰ Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-Cho, Kawaramachi-Hirokoji, Kamigyo-Ku, Kyoto, 602-8566, Japan. mhama@koto.kpu-m.ac.jp.

PMID: 39707434
PMCID: PMC11662526
DOI: 10.1186/s12986-024-00884-y

Abstract

Background: This study aimed to explore the relationship between ultra-processed foods (UPFs) consumption and gut microbiota in patients with type 2 diabetes (T2D).

Methods: This cross-sectional study included 362 participants with T2D. UPFs consumption was assessed using a brief-type self-administered diet history questionnaire, quantified as the density of UPFs intake (g/1000 kcal). Gut microbial composition was evaluated via 16S rRNA gene sequencing. We investigated the association between gut microbiota, previously identified as relevant to T2D, and the density of UPFs intake using Spearman rank correlation coefficients. Multiple regression analysis, adjusting for age, sex, BMI, smoking status, exercise, and medication use, was conducted to further investigate these associations.

Results: The mean age of participants was 68 (63-74) years. The density of UPFs intake showed significant associations with Bifidobacterium (r = 0.11, p = 0.031), Lactobacillus (r = 0.11, p = 0.046), Ruminococcus (r = -0.12, p = 0.019), Roseburia (r = 0.11, p = 0.045). After adjusting for covariates in multiple regression analysis, Ruminococcus and Roseburia showed modest negative (β = -0.11, p = 0.038) and positive (β = 0.12, p = 0.033) correlations, with the density of UPFs intake among participants with T2D, respectively.

Conclusions: The density of UPFs intake was modestly inversely associated with Ruminococcus among patients with T2D and modestly positively associated with Roseburia.

Keywords: Gut microbiota; Type 2 diabetes; Ultra-processed food consumption.

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: The present study received approval by the ethics committee of the Kyoto Prefectural University of Medicine (no. ERB-C-534 and no. RBMR-E-466-5), and adhered to the principles of the Declaration of Helsinki. Written informed consent was obtained from all participants prior enrollment. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.

Figures

**Fig. 1**
Flow diagram for the registration of participants

See this image and copyright information in PMC

References

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Association between gut microbiota and ultra-processed foods consumption among the patients with type 2 diabetes: a cross-sectional study

Affiliations

Association between gut microbiota and ultra-processed foods consumption among the patients with type 2 diabetes: a cross-sectional study

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

References

LinkOut - more resources

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