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Case Reports
. 2024 Dec 21;18(1):632.
doi: 10.1186/s13256-024-04986-2.

Postorgasmic illness syndrome benefiting from omalizumab and antidepressant: a case report

Kasım Okan  1 , Ragıp Fatih Kural  2 , Meryem Demir  2 , Furkan Cot  3 , Mustafa Dinckal  3 , Sevgi Altay  2 , Nihal Mete Gökmen  2
Affiliations
Case Reports

Postorgasmic illness syndrome benefiting from omalizumab and antidepressant: a case report

Kasım Okan et al. J Med Case Rep. .

Abstract

Background: Postorgasmic illness syndrome is characterized by flu, rhinitis, conjunctivitis, loss of appetite, muscle weakness, and fatigue after ejaculation, lasting 2-7 days. The multidisciplinary treatment approach, incorporating omalizumab and antidepressants, has rarely been documented in literature.

Case presentation: In this article, we present the case of a 33-year-old single Turkish male with postorgasmic illness syndrome, characterized by typical clinical symptoms and a positive autologous semen test. Notably, his serum estrogen and progesterone levels were elevated. The patient's Beck anxiety score was 42 points, the depression scale score was 37, and suicidal thoughts. Fresh autologous semen taken at the hospital was diluted with 0.9% saline, and prick and intradermal skin tests were performed.

Conclusion: The patient's symptoms improved significantly with the combination of omalizumab and escitalopram. This case not only provides a new perspective on the management of postorgasmic illness syndrome but also highlights the potential roles of allergic, psychiatric, and endocrinological mechanisms in the etiology and treatment of this complex condition.

Keywords: Allergy; Male orgasmic disorders; Postorgasm illness syndrome; Semen.

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008. Informed consent was obtained from the participant. The original article is not under consideration by another publication, and its substance, tables, or figures have not been published previously and will only be published elsewhere. Consent for publication: Written informed consent was obtained from the patient for publication of this case report and all accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal. Competing interests: The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Postejaculation symptom severity VAS visual analog scale. Sec second, hrhour
Fig. 2
Fig. 2
Graphical representation of clinical course of the patient. The timeline includes the age of disease onset, the age at diagnosis, and the treatments administered based on the response status
See this image and copyright information in PMC

References

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