An intrinsic hierarchical, retinotopic organization of visual pulvinar connectivity in the human neonate

Abstract

The thalamus plays a crucial role in the development of the neocortex, with the pulvinar being particularly important for visual development due to its involvement in various functions that emerge early in infancy. The development of connections between the pulvinar and the cortex constrains its role in infant visual processing and the maturation of associated cortical networks. However, the extent to which adult-like pulvino-cortical pathways are present at birth remains largely unknown, limiting our understanding of how the thalamus may support early vision. To address this gap, we investigated the organization of pulvino-cortical connections in human neonates using probabilistic tractography analyses on diffusion imaging data. Our analyses identified white matter pathways between the pulvinar and areas across occipital, ventral, lateral, and dorsal visual cortices at birth. These pathways exhibited specificity in their connections within the pulvinar, reflecting both an intra-areal retinotopic organization and a hierarchical structure across areas of visual cortical pathways. This organization suggests that even at birth, the pulvinar could facilitate detailed processing of sensory information and communication between distinct processing pathways. Comparative analyses revealed that while the large-scale organization of pulvino-cortical connectivity in neonates mirrored that of adults, connectivity with the ventral visual cortex was less mature than other cortical pathways, consistent with the protracted development of the visual recognition pathway. These findings advance our understanding of the developmental trajectory of thalamocortical connections and provide a framework for how subcortical structures may support early perceptual abilities and scaffold the development of cortex.

Keywords: DTI; development; dorsal stream; lateral stream; newborn; pulvinar; subcortex; thalamocortical connectivity; ventral stream; vision.