CG and LP contributed equally and are joint first authors. XdL and NC contributed equally and are joint last authors. All authors declare no competing interests. Patients (or patients' legal representatives) provided written informed consent for the scientific dissemination of the data. The study was approved by the local ethics committee (Assistance Publique Hôpitaux de Marseille) and registered under the reference PADS BWCRFS. This work was supported by the ARBOGEN project, funded by the MSDAVENIR foundation. The activity of the National Reference Center for Arboviruses is supported by the National Public Health Agency (Santé Publique France, SPF). The activity of Unité des Virus Émergents (UVE) is supported by its supervising institutional bodies (Aix-Marseille Université, Università di Corsica, Institut National de la Santé et de la Recherche Médicale, Institut de Recherche pour le Développement, Institut de Recherche Biomédicale des Armées). The funding sources had no role in the writing of the manuscript or the decision to submit for publication. De-identified individual participant data (clinical features and laboratory results) underlying the findings reported here will be made available immediately following publication. Requests should be directed to the corresponding author. Genomic sequences are publicly available at: https://github.com/rklitting/OROV_cluster_FRA-2024. We are thankful to the personnel of UVE and National Reference Center for Arboviruses involved in this project for their excellent technical support. We thank Boris Pastorino for valuable assistance for laboratory tests at UVE, and Dominique Rousset and the Associated National Reference Center for Arboviruses, Institut Pasteur in French Guiana for providing the Oropouche virus strain used for virus neutralisation test. RT-qPCR assays for arbovirus detection were provided by the European virus archive-Marseille (EVAM) under the label Technological Platforms of Aix-Marseille.