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Review
. 2024 Dec 23;45(1):20.
doi: 10.1007/s10792-024-03331-2.

Near-infrared imaging retinal diagnostic applications-a review

Affiliations
Review

Near-infrared imaging retinal diagnostic applications-a review

Or Shmueli et al. Int Ophthalmol. .

Abstract

Objective: Near-infrared reflectance (NIR) is a commonly performed noncontact and rapid imaging technique. This paper reviews the clinical applications of NIR for diagnosing and monitoring retinal diseases.

Methods: A comprehensive search was conducted across the Pubmed database. A total of 105 articles were finally included in this article. Images were acquired from the authors own clinical experience.

Results: The article describes the imaging utility of NIR for diagnosing and deomonstrating findings in various conditions. These include retinal vascular diseases, age-related macular degeneration (AMD), vitreoretinal interface pathologies, retinal dystrophies, inflammatory chorioretinopathies, phakomatoses, retinal toxicities, photic injury, choroidal cavitary lesions, choroidal neoplasms, and choroidal Vascular Lesions.

Conclusion: NIR is widely acquired during OCT imaging, and is advantageous at imaging with low illumination levels and through narrow pupils or opaque media. NIR offers valuable information for the diagnosis and follow-up of retinal disease, and is highly recommended to utilize for clinical decision-making in ophthalmology.

Keywords: Applications; Diagnosis; Infra-red imaging; Retina; Review.

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Conflict of interest statement

Declarations. Conflict of interest: The authors declare no competing interests. Ethics approval: This study was performed in line with the principles of the Declaration of Helsinki. Approval was obtained from the Institutional Review (IRB)Boards/Ethics Committees of Hadassah-Hebrew University Medical Center, Jerusalem, Israel (approval number 0382–19) and the Centre for Eye Research Australia, Royal Victorian Eye, and Ear Hospital, East Melbourne, Australia (approval number 21-1517HL). Consent to participate: Both Ethics Committees waived the requirement for informed consent for participation in this study owing to the retrospective and anonymous nature of data analysis.

References

    1. Keilhauer CN, Delori FC (2006) Near-infrared autofluorescence imaging of the fundus: visualization of ocular melanin. Investig Opthalmol Visual Sci 47:3556. https://doi.org/10.1167/iovs.06-0122 - DOI
    1. Weinberger AWA, Lappas A, Kirschkamp T et al (2006) Fundus near infrared fluorescence correlates with fundus near infrared reflectance. Investig Opthalmol Visual Sci 47:3098. https://doi.org/10.1167/iovs.05-1104 - DOI
    1. Ly A, Nivison-Smith L, Assaad N, Kalloniatis M (2016) Infrared reflectance imaging in age-related macular degeneration. Ophthalmic Physiol Opt 36:303–316. https://doi.org/10.1111/opo.12283 - DOI - PubMed - PMC
    1. Gibbs D, Cideciyan AV, Jacobson SG, Williams DS (2009) Retinal pigment epithelium defects in humans and mice with mutations in MYO7A : imaging melanosome-specific autofluorescence. Investig OpthalmolVisual Sci 50:4386. https://doi.org/10.1167/iovs.09-3471 - DOI
    1. Elsner AE, Burns SA, Weiter JJ, Delori FC (1996) Infrared imaging of sub-retinal structures in the human ocular fundus. Vision Res 36:191–205 - DOI - PubMed

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