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Clinical Trial
. 2024 Dec 22;33(1):50.
doi: 10.1007/s00520-024-09085-y.

Enteral nutrition support in patients with cancer: association of short-term prognosis and medical costs with inflammation

Chenan Liu #  1   2   3   4 , Li Deng #  1   2   3   4 , Shiqi Lin #  1   2   3   4 , Tong Liu  1   2   3   4 , Jiangshan Ren  5 , Jinyu Shi  1   2   3   4 , Heyang Zhang  1   2   3   4 , Hailun Xie  1   2   3   4 , Yue Chen  1   2   3   4 , Xin Zheng  1   2   3   4 , ZhaoTing Bu  1   2   3   4 , Hanping Shi  6   7   8   9
Affiliations
Clinical Trial

Enteral nutrition support in patients with cancer: association of short-term prognosis and medical costs with inflammation

Chenan Liu et al. Support Care Cancer. .

Abstract

Background: Enteral nutrition (EN) is commonly used for nutritional support in patients with cancer. Whether inflammation, one of the driving factors of malnutrition and cancer, affects the association between EN and short-term prognosis and medical costs in patients with cancer remains unclear. We aimed to investigate the association between EN and short-term prognosis of patients with cancer and the effect of inflammation on EN-associated medical costs.

Methods: This multicentre prospective cohort study evaluated patients with pathologically confirmed solid tumours. After admission, all patients who received EN, including oral or tube feeding, were assigned to the EN group. The log-rank test was used to identify the optimal cutoff values for inflammatory markers. Cox regression analysis was used to analyse the associations among EN, inflammation, and prognosis. Propensity score matching was used to balance biases between the EN and non-EN groups and validate the stability of the results.

Results: A total of 5121 patients were included, with 2965 (57.90%) men and an average age of 59.06 (11.30) years. A total of 462 patients received EN, with 390 (84.4%) receiving oral nutritional supplementation. During the 90-day follow-up, 304 patients died. In the low inflammation group, there was no association between EN and short-term prognosis (hazard ratio [HR] = 0.92, 95% confidence interval [CI] = 0.39-2.18). In the high inflammation group, EN significantly improved the short-term prognosis (HR = 0.48, 95% CI = 0.30-0.76). In patients with low inflammation (p < 0.001), EN increased hospitalisation costs (p < 0.001) without reducing length of stay (LOS) (p = 0.15). In patients with high inflammation, EN did not increase hospitalisation expenses (p = 0.47) but reduced the LOS (p = 0.004).

Conclusion: EN can improve the short-term prognosis of patients with high inflammation and reduce LOS without increasing the hospitalisation expenses. Baseline inflammation levels may serve as effective indicators for personalised and precise EN treatment.

Clinical trial registration: ChiCTR1800020329 (chictr.org.cn).

Keywords: Cancer; Enteral nutrition; Inflammation; Medical costs; Short-term prognosis.

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Conflict of interest statement

Declarations. Ethics approval: This study was approved by the ethics committee of Beijing Shijitan Hospital and adhered to the principles of the Declaration of Helsinki. Consent to participate: Participants or their legal representatives provided written informed consent. Conflict of interest: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Flow chart
Fig. 2
Fig. 2
The differences in hospitalisation expenses and LOS between patients who received EN and those who did not receive EN at various levels of inflammation
See this image and copyright information in PMC

Comment in

References

    1. Dolgin E (2021) Cancer’s new normal. Nat Cancer 2:1248–1250 - DOI - PubMed
    1. Zhang KP, Tang M, Fu ZM et al (2021) Global Leadership Initiative on Malnutrition criteria as a nutrition assessment tool for patients with cancer. Nutrition 91–92:111379 - DOI - PubMed
    1. Bossi P, Delrio P, Mascheroni A, Zanetti M (2021) The spectrum of malnutrition/cachexia/sarcopenia in oncology according to different cancer types and settings: a narrative review. Nutrients 13:1980 - DOI - PMC - PubMed
    1. Park JH, Kim E, Seol EM et al (2021) Prediction model for screening patients at risk of malnutrition after gastric cancer surgery. Ann Surg Oncol 28:4471–4481 - DOI - PubMed
    1. Chow R, Bruera E, Chiu L et al (2016) Enteral and parenteral nutrition in cancer patients: a systematic review and meta-analysis. Ann Palliat Med 5:30–41 - PubMed