Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Jan 20:12:100441.
doi: 10.1016/j.ijcchd.2023.100441. eCollection 2023 Jun.

Cancer risk in adult congenital heart disease

Suvasini Lakshmanan  1 , Alessia Gimelli  2
Affiliations
Review

Cancer risk in adult congenital heart disease

Suvasini Lakshmanan et al. Int J Cardiol Congenit Heart Dis. .

Abstract

Advances in diagnostics and interventional/surgical treatment of patients with congenital heart disease (CHD) over the past several decades, allows a decline in rates of all-cause mortality, with a significant reduction in proportion of infant and childhood deaths with severe forms of CHD. However, the risk of premature death in adults with complex CHD remains elevated. A growing body of evidence has recently described the impact of non-cardiovascular comorbidities such as cancers, on morbidity, health care utilizations and mortality in adult patients with CHD. Aim of this review is to provide an appraisal of the current evidence that report associations between CHD and increased cancer risk in children and adults, and provide an overview of the specific risk factors.

Keywords: Cancer risk; Congenital heart disease; Genetics; Imaging; Radiation dose.

PubMed Disclaimer

Figures

Image 1
Graphical abstract
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Khairy P., Ionescu-Ittu R., Mackie A.S., Abrahamowicz M., Pilote L., Marelli A.J. Changing mortality in congenital heart disease. J Am Coll Cardiol. 2010;56:1149–1157. - PubMed
    1. Greutmann M., Tobler D. Changing epidemiology and mortality in adult congenital heart disease: looking into the future. Future Cardiol. 2012;8:171–177. - PubMed
    1. Cohen S., Gurvitz M.Z., Beauséjour-Ladouceur V., Lawler P.R., Therrien J., Marelli A.J. Cancer risk in congenital heart disease-what is the evidence? Can J Cardiol. 2019;35:1750–1761. - PubMed
    1. Mandalenakis Z., Karazisi C., Skoglund K., et al. Risk of cancer among children and young adults with congenital heart disease compared with healthy controls. JAMA Netw Open. 2019;2 - PubMed
    1. Karazisi C., Dellborg M., Mellgren K., et al. Risk of cancer in young and older patients with congenital heart disease and the excess risk of cancer by syndromes, organ transplantation and cardiac surgery: Swedish health registry study (1930-2017) Lancet Reg Health Eur. 2022;18 - PMC - PubMed

LinkOut - more resources