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Review
. 2024 Nov 22;16(11):e74258.
doi: 10.7759/cureus.74258. eCollection 2024 Nov.

Experimental Models in Penile Transplantation: Translational Insights and Relevance to Clinical Application

Naga Anvesh Kodali  1 , Ramu Janarthanan  1   2 , Bedreddin Sazoglu  1 , Zeynep Demir  1 , Omer Faruk Dirican  1 , Yalcin Kulahci  1 , Fatih Zor  3 , Vijay S Gorantla  1
Affiliations
Review

Experimental Models in Penile Transplantation: Translational Insights and Relevance to Clinical Application

Naga Anvesh Kodali et al. Cureus. .

Abstract

Animal research is an essential contributor to the medical achievements of the last century. The first step of studying a disease in animals is the development of a model which is relevant to the clinical situation in humans. Thus, a good animal model is the sine qua non of the experimental research. This review aims to assess the contemporary literature on animal models for penile transplantation, examining their applicability and significance in the context of clinical scenarios. We also revisit, evaluate, and emphasize the interesting and important findings of certain animal models to bring the reader up to date from the perspective of allotransplantation. Their current and future clinical applicability and feasibility have been discussed, shedding light on worldwide experience in Vascularized Composite Allotransplantation (VCA).

Keywords: experimental models; penile transplantation; penis; vascularized composite allotransplantation; vca.

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Conflict of interest statement

Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

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