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Review
. 2024 Nov 22;16(11):e74238.
doi: 10.7759/cureus.74238. eCollection 2024 Nov.

Rheumatoid Arthritis and Heart Failure: A Narrative Review

Korimerla Deepika  1 , Sai Lokesh Moraboina  1 , Bodipudi Vineetha  1 , Chandana Sai Kodali  1 , Hema Sreelakshmi Guddeti  1 , Sanjana Poladi  2 , Chandana Priya Digumurthy  1 , Jashika Mellamputi  3
Affiliations
Review

Rheumatoid Arthritis and Heart Failure: A Narrative Review

Korimerla Deepika et al. Cureus. .

Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory process involving the joints and the cartilage. Early diagnosis and treatment of RA are crucial to prevent further complications like heart failure (HF), cervical subluxation, membranous glomerulonephritis, and parenchymal lung disease. HF is the leading cause of death in various chronic illnesses. The pathophysiology of HF varies based on the type of illness. In this review, our main objective was to look into the association between RA and HF by examining the pathogenesis, risk factors, and treatment of HF in RA. We also discuss the role of the inflammatory markers associated with HF in the pathogenesis. The treatment of anti-inflammatory drugs in HF associated with RA is also discussed. We also address the risk factors associated with RA so that the development of complications like HF can be reduced in this patient population.

Keywords: anti-cyclic citrullinated peptide; heart failure; inflammatory markers; rheumatoid arthritis; tnf alpha inhibitors.

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Conflict of interest statement

Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. Pathogenesis of heart failure in rheumatoid arthritis
Anti-CCP: anti-cyclic citrullinated peptide antibodies; Apo A-1: apoprotein A-1; CD-4: cluster of differentiation; CRP: C-reactive protein; HDL: high-density lipoprotein; ICAM: intercellular adhesion molecule; IL-6: interleukin-6; TNF-alpha: tumor necrosis factor-alpha Image credits: Dr. Deepika Korimerla
See this image and copyright information in PMC

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References

    1. Epidemiology, pathophysiology, and diagnosis of rheumatoid arthritis: a synopsis. Gibofsky A. https://pubmed.ncbi.nlm.nih.gov/25180621/ Am J Manag Care. 2014;20:0–35. - PubMed
    1. Epidemiology and genetics of rheumatoid arthritis. Silman AJ, Pearson JE. Arthritis Res. 2002;4:0–72. - PMC - PubMed
    1. Heart failure: a special issue. van der Velden J, de Tombe PP. Pflugers Arch. 2014;466:1023. - PMC - PubMed
    1. Overview of epidemiology, pathophysiology, and diagnosis of rheumatoid arthritis. Gibofsky A. https://pubmed.ncbi.nlm.nih.gov/23327517/ Am J Manag Care. 2012;18:0–302. - PubMed
    1. Prevalence, risk factors and proteomic bioprofiles associated with heart failure in rheumatoid arthritis: the RA-HF study. Ferreira MB, Fonseca T, Costa R, et al. Eur J Intern Med. 2021;85:41–49. - PubMed

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