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Review
. 2024 Dec 18:17:2967-2988.
doi: 10.2147/CCID.S502252. eCollection 2024.

Natural Modulators of Key Signaling Pathways in Skin Inflammageing

Qianqian Ren  1 , Liping Qu  2 , Yonglei Yuan  3 , Feifei Wang  2
Affiliations
Review

Natural Modulators of Key Signaling Pathways in Skin Inflammageing

Qianqian Ren et al. Clin Cosmet Investig Dermatol. .

Abstract

Low-grade chronic inflammation without obvious infection is defined as "inflammageing" and a key driver of skin ageing. Although the importance of modulating inflammageing for treating skin diseases and restoring cutaneous homeostasis is increasingly being recognized. However, the mechanisms underlying skin inflammageing, particularly those associated with natural treatments, have not been systematically elucidated. This review explores the signaling pathways associated with skin inflammageing, as well as the natural plants and compounds that directly or indirectly target these pathways. Nine signaling pathways and 60 plants/constituents related to skin anti-inflammageing are discussed, exploring plant mechanisms to mitigate skin inflammageing. Common natural plants with anti-inflammageing activity are detailed by active ingredients, mechanisms, therapeutic potential, and quantitative effects on skin inflammageing modulation. This review strengthens our understanding of these botanical ingredients as natural interventions against skin inflammageing and provides directions for future research.

Keywords: cutaneous homeostasis; inflammageing; plant extract; skin ageing.

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Conflict of interest statement

The authors declare no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Cellular signaling pathways involved in the regulation of skin inflammaging. Imbalances in skin-related inflammation leads to skin aging.
Figure 2
Figure 2
Cells and molecules involved in skin inflammaging. In the process of skin inflammageing, keratinocytes, fibroblasts, melanocytes, and immune cells secrete SASP. SASP further causes aging of surrounding young cells, forming a vicious cycle.
Figure 3
Figure 3
(a) The core regulatory pathways involved skin inflammaging (including NF-κB/RIG-I, mTOR, TGF-β, AMPK–SIRTs pathways). Created in BioRender. Ren, Q. (2024) https://BioRender.com/s82l596. (b) The other regulatory pathways of skin inflammaging (including complement system, NLRP3, Notch, JAK–STAT, and MAPK pathways). Created in BioRender. Ren, Q. (2024) https://BioRender.com/h71i391.
See this image and copyright information in PMC

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