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. 2024 Sep 16;4(5):100360.
doi: 10.1016/j.bpsgos.2024.100360. eCollection 2024 Sep.

Unraveling Autism: Using Brain Organoids to Investigate Sex Differences in Brain Development

Max Mitchell  1   2 , Aleksandra Spasova  1   2 , Yasir Ahmed Syed  1   2
Affiliations

Unraveling Autism: Using Brain Organoids to Investigate Sex Differences in Brain Development

Max Mitchell et al. Biol Psychiatry Glob Open Sci. .
No abstract available

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Figures

Figure 1
Figure 1
Illustrative representation of modeling sex differences in brain organoids associated with ASD. Brain region–specific organoids can be exposed to various environmental and hormonal factors or studied for the effects of ASD-associated genetic mutations, providing insight into the underlying sex-specific mechanisms in brain development (top lane). These differences in organoids can be characterized by evaluating morphological variations, neuronal connectivity, tissue architecture and maturation, cellular diversity, and in screening of drug candidates (bottom lane). ASD, autism spectrum disorder.
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