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Review
. 2024 Dec 23;163(1):19.
doi: 10.1007/s00418-024-02348-z.

Effect of bone marrow niche on hematopoietic stem cells

Vahid Niazi  1   2 , Soudeh Ghafouri-Fard  3
Affiliations
Review

Effect of bone marrow niche on hematopoietic stem cells

Vahid Niazi et al. Histochem Cell Biol. .

Abstract

Hematopoietic stem cells (HSCs) reside in a milieu that supports their functions, differentiation, and survival. This niche consists of several types of cells, including mesenchymal stem/stromal cells, endothelial cells, osteoblasts, megakaryocytes, macrophages, adipocytes, lymphoid cells, and nerve fibers. The interactions between these cells and HSCs have a role in HSC fate. Several studies have focused on identification of the biological and cellular mechanisms contributing to the establishment of this niche. However, the exact mechanisms of the interaction between HSCs and the bone marrow niche have not been elucidated yet. Unraveling these mechanisms would help in the design of effective methods for maintenance and multiplication of HSCs in clinical settings, in addition to establishment of novel therapies for hematopoietic diseases. The current review summarizes the effects of the niche cells on HSC function and underlying mechanisms of interplay between HSCs and their niche.

Keywords: Bone marrow niche; Hematopoietic stem cells; Mesenchymal stem cells.

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Conflict of interest statement

Declarations. Conflict of interest: The authors declare no competing interests. Ethical approval and consent to participate: Not applicable. Consent for publication: Not applicable.

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