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Controlled Clinical Trial
. 2024 Dec 23;14(1):30615.
doi: 10.1038/s41598-024-83846-x.

Telemedicine-based exercise intervention in cancer survivors: a non-randomized controlled trial

Verena Krell  1   2 , Johanna Porst  3   4 , Lorena Hafermann  5 , Jessica Kuhn  3   4 , Franziska Greiß  3   4 , Claudia Römer  6 , Bernd Wolfarth  3   4
Affiliations
Controlled Clinical Trial

Telemedicine-based exercise intervention in cancer survivors: a non-randomized controlled trial

Verena Krell et al. Sci Rep. .

Abstract

Cancer survivors (CS) often experience treatment-related side effects, such as fatigue, and have reduced physical function. Regular physical activity has been demonstrated to reduce these symptoms and improve cardiopulmonary fitness. Digital solutions are needed to optimize exercise options for CS in aftercare, especially given the significant limitations during the Covid-19 pandemic. This two-armed, non-randomized, controlled intervention study for CS aims to investigate whether a telemedicine-based exercise intervention is as effective as the current standard of care for oncological exercise therapy in aftercare. Patients in the intervention group (n = 61) performed a telemedicine-based exercise program (TE) and patients in the control group (n = 31) participated in an existing rehabilitation sports group (RG) over a six-month intervention period. The primary outcome was cardiopulmonary fitness measured by VO2peak; secondary outcomes included quality of life (QoL), fatigue, and physical activity. A non-inferiority analysis was performed with a predefined non-inferiority margin for relative VO2peak of -1.50 ml/min/kg. Although TE demonstrated a slight advantage in relative VO2peak compared to RG (adjusted mean difference of 0.55 ml/min/kg [95% CI: -2.74; 3.84]), the non-inferiority was not statistically significant. Nevertheless, the implementation of a telemedicine-based exercise intervention indicates that individual patients respond well to this type of exercise program and benefit from the intervention, particularly in terms of QoL. Finding an individualized program for each cancer survivor is the overarching goal. A telemedicine-based exercise intervention may be a promising option, particularly for younger patients.

Keywords: COVID-19; Cancer survivors; Controlled study; Exercise oncology; Supportive cancer care; Wearable activity tracker.

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Conflict of interest statement

Declarations. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Flowchart from enrollment to analysis including dropouts.
Fig. 2
Fig. 2
Mean changes of cardiopulmonary fitness, quality of life, fatigue and physical activity by treatment group between baseline (V0) and after six months intervention (V1).
See this image and copyright information in PMC

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