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Meta-Analysis
. 2024 Dec 24;24(1):490.
doi: 10.1186/s12883-024-03990-9.

Repetitive transcranial magnetic stimulation improves cognition, depression, and walking ability in patients with Parkinson's disease: a meta-analysis

Mingchen Wang  1   2 , Wenyu Zhang  3 , Wanli Zang  4
Affiliations
Meta-Analysis

Repetitive transcranial magnetic stimulation improves cognition, depression, and walking ability in patients with Parkinson's disease: a meta-analysis

Mingchen Wang et al. BMC Neurol. .

Abstract

Objective: To evaluate the efficacy of repetitive transcranial magnetic stimulation (rTMS) on cognitive function, depression, and walking ability in patients with Parkinson's disease.

Methods: A comprehensive search was conducted in PubMed, Web of Science, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database (CBM), VIP Database, and Wanfang Database. Randomized controlled trials (RCTs) on rTMS treatment in Parkinson's disease patients were retrieved, covering the period from the inception of each database to July 2024. The quality of the included studies was assessed using the Cochrane risk of bias tool. Two researchers independently screened the literature, extracted data, and assessed the risk of bias in the studies. Data synthesis and analysis were performed using RevMan 5.4 and Stata 17.0 software.

Results: A total of 15 studies were included. The meta-analysis revealed that rTMS significantly improved the MOCA score (MD = 2.98, 95% CI 2.08, 3.88, P = 0.000), TUGT score (SMD=-0.72, 95% CI -1.43, 0.00, P = 0.048), FOG-Q score (SMD=-0.54, 95% CI -0.97, -0.11, P = 0.01), and UPDRS-III score (SMD=-0.66, 95% CI -0.84, -0.47, P = 0.000) in Parkinson's disease patients, and also alleviated depressive symptoms as measured by the HAMD (SMD=-0.43, 95% CI -0.72, -0.13, P = 0.004).

Conclusions: rTMS can improve cognitive function, depressive symptoms, and walking ability in patients with Parkinson's disease.

Keywords: Cognitive function; Gait; Meta-analysis; Repetitive transcranial magnetic stimulation; Walking ability.

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Conflict of interest statement

Declarations. Ethical approval and consent to participate: This article contains no studies with human participants or animals performed by any authors. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Literature screening flowchart
Fig. 2
Fig. 2
Risk assessment chart. A Risk of bias graph. B Risk of bias summary
Fig. 3
Fig. 3
Meta-analysis results. A MOCA. B HAMD. C TUGT. D FOG-Q. E UPDRSIII
Fig. 4
Fig. 4
HAMD subgroup analysis
Fig. 5
Fig. 5
TUGT subgroup analysis
Fig. 6
Fig. 6
UPDRSIII funnel plot
See this image and copyright information in PMC

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