Augmenting anti-inflammatory macrophage function in colitis: a neuroimmune mechanism to drive intestinal wound repair

Natalie Bhesania^{1

2}, Michael A Schumacher^{1

2}

Affiliations

¹ Department of Pediatrics, University of Southern California Keck School of Medicine, Los Angeles, California, United States.
² Division of Gastroenterology, Hepatology, and Nutrition, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, California, United States.

Comment

Natalie Bhesania et al. Am J Physiol Gastrointest Liver Physiol. 2025.

. 2025 Feb 1;328(2):G94-G95.

doi: 10.1152/ajpgi.00368.2024. Epub 2024 Dec 23.

Natalie Bhesania^{1

2}, Michael A Schumacher^{1

2}

¹ Department of Pediatrics, University of Southern California Keck School of Medicine, Los Angeles, California, United States.
² Division of Gastroenterology, Hepatology, and Nutrition, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, California, United States.

No abstract available

Keywords: CGRP; IBD; interleukin-4; macrophages.

Conflict of interest statement

DISCLOSURES

No conflicts of interest, financial or otherwise, are declared by the authors.

Calcitonin gene-related peptide promotes epithelial reparative and anticolitic functions of IL-4 educated human macrophages.
Callejas BE, Sousa JA, Flannigan KL, Wang A, Higgins E, Herik AI, Li S, Rajeev S, Rosentreter R, Panaccione R, McKay DM. Callejas BE, et al. Am J Physiol Gastrointest Liver Physiol. 2025 Jan 1;328(1):G1-G16. doi: 10.1152/ajpgi.00159.2024. Epub 2024 Oct 8. Am J Physiol Gastrointest Liver Physiol. 2025. PMID: 39378308

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