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Review
. 2024 Dec 23;16(12):e76250.
doi: 10.7759/cureus.76250. eCollection 2024 Dec.

Principles of Fracture Healing and Fixation: A Literature Review

Mohammad Waseem Beeharry  1 , Belal Ahmad  1
Affiliations
Review

Principles of Fracture Healing and Fixation: A Literature Review

Mohammad Waseem Beeharry et al. Cureus. .

Abstract

Bone healing is a complex, dynamic process involving a series of well-coordinated stages, influenced by both mechanical and biological factors. The skeletal system, composed of inorganic (36%), organic (36%), and water (28%) components by volume, plays a crucial role in maintaining structural integrity and mineral homeostasis. Bone is classified into two main types based on microstructure: lamellar and woven bone, with lamellar bone being stronger and more durable. Factors such as inflammation, the periosteum, vascularity, and infection significantly impact healing outcomes. Moreover, fracture fixation is fundamental to optimal healing, guided by principles of anatomical reduction, stable fixation, blood supply preservation, and early mobilisation. Perren's strain theory emphasises the importance of strain at the fracture site, which can determine whether primary or secondary healing occurs. Rigid fixation provides an environment which promotes primary bone healing, while flexible fixation promotes secondary healing through controlled motion. Internal and external fixation methods, including plates, screws, and intramedullary nails, offer varying degrees of stability, supporting bone healing. Overall, optimal fracture fixation, combined with an understanding of bone biology, enhances healing and functional recovery.

Keywords: fixation constructs; fracture fixation; fracture healing; principles of fracture fixation; stages of fracture healing.

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Conflict of interest statement

Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. Perren's strain theory
Figure 1 is an original work of the authors
See this image and copyright information in PMC

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