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. 2024 Mar;4(1):64-83.
doi: 10.3390/dna4010004. Epub 2024 Feb 22.

Chromatin Organization during C. elegans Early Development

Eshna Jash  1 , Györgyi Csankovszki  1
Affiliations

Chromatin Organization during C. elegans Early Development

Eshna Jash et al. DNA (Basel). 2024 Mar.

Abstract

Embryogenesis is characterized by dynamic chromatin remodeling and broad changes in chromosome architecture. These changes in chromatin organization are accompanied by transcriptional changes, which are crucial for the proper development of the embryo. Several independent mechanisms regulate this process of chromatin reorganization, including segregation of chromatin into heterochromatin and euchromatin, deposition of active and repressive histone modifications, and the formation of 3D chromatin domains such as TADs and LADs. These changes in chromatin structure are directly linked to developmental milestones such as the loss of developmental plasticity and acquisition of terminally differentiated cell identities. In this review we summarize these processes that underlie this chromatin reorganization and their impact on embryogenesis in the nematode C. elegans.

Keywords: LADs; TADs; chromatin; dosage compensation; embryo development; histone modifications.

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Conflict of interest statement

Conflicts of Interest: The authors declare no conflict of interest.

Figures

Figure 1:
Figure 1:
Schematic representation of tethering pathways for heterochromatin and telomeric chromatin
Figure 2:
Figure 2:
Timeline of chromatin reorganization during embryogenesis.
See this image and copyright information in PMC

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