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Case Reports
. 2024 Dec 23:12:2050313X241309094.
doi: 10.1177/2050313X241309094. eCollection 2024.

Two case reports of MDA5-type seronegative dermatomyositis

Lauren C Balogh  1 , Airiss R Chan  2 , Elaine A Yacyshyn  3 , Robert Gniadecki  2
Affiliations
Case Reports

Two case reports of MDA5-type seronegative dermatomyositis

Lauren C Balogh et al. SAGE Open Med Case Rep. .

Abstract

Dermatomyositis (DM) is an autoimmune idiopathic inflammatory myopathy with characteristic dermatologic manifestations. Myositis-specific autoantibodies (MSAs) delineate DM subtypes and their prognoses. Uncommonly, patients present with distinct clinical features of DM, including photosensitive dermatitis, heliotrope rash, Gottron's papules, and nailfold changes; however, their autoimmune serology is negative for expected MSAs. Herein, we describe two unconventional cases of seronegative, amyopathic MDA5-DM and offer potential explanations, including fluctuating antibody levels, non-MSA pathophysiology, and limitations in current immunoassays.

Keywords: Dermatomyositis; MDA5; autoimmune; seronegative.

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Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Clinical presentation of seronegative dermatomyositis in two patients. (a–d) shows (a) shawl sign, (b) Gottron’s papules, (c) digital ulcerations, and (d) capillary dropout in patient one, (e) and (f) show periungual erythema with onycholysis and edema in patient two.
See this image and copyright information in PMC

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