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Review
. 2024 Dec 29;75(4):240-244.
doi: 10.2478/aiht-2024-75-3918. eCollection 2024 Dec 1.

What is more common in fatal caffeine intoxication - suicide or unintentional overdose?

Affiliations
Review

What is more common in fatal caffeine intoxication - suicide or unintentional overdose?

Dražen Lušić et al. Arh Hig Rada Toksikol. .

Abstract

Caffeine is a natural stimulant of plant origin found in many products such as coffee, tea, chocolate, and energy drinks. It is also often used as an active substance in over-the-counter drugs such as painkillers and preparations for the treatment of colds and allergies. While caffeine is generally considered safe when moderately consumed, excessive intake in a single dose or through repeated small doses over time can lead to caffeine intoxication. Symptoms of caffeine intoxication can vary depending on the amount of caffeine consumed and can include restlessness, rapid heart rate, muscle tremors, nausea, vomiting, and confusion. In severe cases, caffeine intoxication can lead to convulsions, coma, and even death. This mini-review presents an overview of caffeine's characteristics and intoxication including symptoms, causes, diagnosis, and treatment. It addresses risk factors associated with caffeine intoxication and presents current recommendations for safe caffeine consumption. The studies we have reviewed suggest that in cases of fatal caffeine intoxications, intentional intoxication is more common than unintentional.

Kofein je prirodni stimulans biljnog podrijetla koji se nalazi u mnogim prehrambenim proizvodima poput kave, čaja, čokolade i energetskih napitaka. Također, često se koristi kao jedna od aktivnih tvari u bezreceptnim lijekovima poput lijekova protiv bolova i pripravaka za liječenje prehlade i alergija. Dok se kofein općenito smatra sigurnim ako se umjereno konzumira, pretjerani unos u jednoj dozi ili ponavljanim malim dozama tijekom vremena može dovesti do otrovanja kofeinom. Simptomi otrovanja kofeinom ovise o količini konzumiranog kofeina i mogu uključivati nemir, ubrzan rad srca, drhtanje, mučninu, povraćanje i zbunjenost. Teški slučajevi otrovanja kofeinom moge dovesti do konvulzija, kome, pa čak i smrti. U ovom su preglednom radu prikazane karakteristike otrovanja kofeinom uključujući uzroke, simptome, dijagnozu i liječenje. Opisani su čimbenici rizika povezani s otrovanjem kofeinom te navedene trenutne preporuke za sigurnu konzumaciju kofeina. Iz rezultata objavljenih istraživanja prikazanih u ovome preglednom radu može se zaključiti da je u slučajevima smrtonosnih otrovanja kofeinom, namjerno otrovanje češće nego slučajno.

Keywords: bezreceptni lijek; coffee; energetski napitak; energy drink; intentional intoxication; kava; namjerno otrovanje; over-the-counter drugs; slučajno otrovanje; unintentional intoxication.

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Conflict of interest statement

Conflict of interest

The authors declare no conflict of interest.

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