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. 2025 Jul;55(7):986-995.
doi: 10.1007/s00595-024-02984-x. Epub 2024 Dec 24.

Preventive effect of Clostridium butyricum MIYAIRI against pouchitis in children with ulcerative colitis

Yuhki Koike  1 , Koki Higashi  1 , Yuki Sato  1 , Shinji Yamashita  1 , Yuka Nagano  1 , Tadanobu Shimura  1 , Takahito Kitajima  2 , Kohei Matsushita  1 , Yoshinaga Okugawa  2 , Yoshiki Okita  1 , Mikihiro Inoue  3 , Keiichi Uchida  4 , Yuji Toiyama  5
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Preventive effect of Clostridium butyricum MIYAIRI against pouchitis in children with ulcerative colitis

Yuhki Koike et al. Surg Today. 2025 Jul.

Abstract

Purpose: Pouchitis is a major complication after ileal pouch-anal anastomosis (IPAA) for ulcerative colitis in children (UCc). In this study, we investigated whether the oral administration of Clostridium butyricum MIYAIRI 588 (CBM) can reduce the incidence of pouchitis after IPAA in UCc.

Methods: We reviewed the data for pediatric patients with UC, who underwent IPAA in Mie University Hospital between 2004 and 2022. Data on the presence and type of postoperative probiotic medication and the timing of probiotic initiation, as well as clinical variables, were collected from the patients' medical records.

Results: During the study period, 55 children with UC underwent radical surgery. During the first 5 years after ileostomy closure, 23 (41.8%) patients suffered at least one pouchitis episode. The incidence of acute pouchitis was significantly lower in the CBM group than in the non-CBM group (CBM vs. non-CBM: 10.5% vs. 58.3%, p < 0.01). Furthermore, even among patients who had been taking any probiotics postoperatively, the CBM group had a significantly lower incidence of both acute and chronic pouchitis than the 'other probiotics' group (p < 0.01).

Conclusion: Oral CBM administration after ileostomy closure may be effective in preventing postoperative pouchitis.

Keywords: Clostridium butyricum; Children; Pouchitis; Probiotics; Ulcerative colitis.

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Conflict of interest statement

Declarations. Conflict of interest: We have no conflicts of interest to declare for this article.

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References

    1. Jakobsen C, Bartek J Jr, Wewer V, Vind I, Munkholm P, Groen R, et al. Differences in phenotype and disease course in adult and paediatric inflammatory bowel disease–a population-based study. Aliment Pharmacol Ther. 2011;34:1217–24. - DOI - PubMed
    1. Van Limbergen J, Russell RK, Drummond HE, Aldhous MC, Round NK, Nimmo ER, et al. Definition of phenotypic characteristics of childhood-onset inflammatory bowel disease. Gastroenterology. 2008;135:1114–22. - DOI - PubMed
    1. Shen B, Fazio VW, Remzi FH, Delaney CP, Bennett AE, Achkar JP, et al. Comprehensive evaluation of inflammatory and noninflammatory sequelae of ileal pouch-anal anastomoses. Am J Gastroenterol. 2005;100:93–101. - DOI - PubMed
    1. Coffey JC, Winter DC, Neary P, Murphy A, Redmond HP, Kirwan WO. Quality of life after ileal pouch-anal anastomosis: an evaluation of diet and other factors using the Cleveland Global Quality of Life instrument. Dis Colon Rectum. 2002;45:30–8. - PubMed
    1. Shen B. Acute and chronic pouchitis–pathogenesis, diagnosis and treatment. Nat Rev Gastroenterol Hepatol. 2012;9:323–33. - DOI - PubMed

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