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. 2025 Apr 15;231(4):e708-e712.
doi: 10.1093/infdis/jiae634.

Staphylococcus aureus Tetracycline Resistance and Co-resistance in a Doxycycline Postexposure Prophylaxis-Eligible Population

Rachel Mittelstaedt  1   2 , Sanjat Kanjilal  3   4 , David Helekal  2 , Gregory K Robbins  1 , Yonatan H Grad  2
Affiliations

Staphylococcus aureus Tetracycline Resistance and Co-resistance in a Doxycycline Postexposure Prophylaxis-Eligible Population

Rachel Mittelstaedt et al. J Infect Dis. .

Abstract

Among doxycycline postexposure prophylaxis (doxy-PEP)-eligible men, Staphylococcus aureus tetracycline nonsusceptibility is more prevalent than in the overall population and is associated with resistance to trimethoprim-sulfamethoxazole and clindamycin. Doxy-PEP may select for multidrug-resistant S aureus, underscoring the importance of surveillance.

Keywords: Staphylococcus aureus; doxy-PEP; doxycycline postexposure prophylaxis.

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Conflict of interest statement

Potential conflicts of interest . All authors: No reported conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.

Figures

Figure 1.
Figure 1.
Cohort identification schematic. Abbreviations: HIV, human immunodeficiency virus; PrEP, preexposure prophylaxis.
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