Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Apr 15;231(4):e708-e712.
doi: 10.1093/infdis/jiae634.

Staphylococcus aureus Tetracycline Resistance and Co-resistance in a Doxycycline Postexposure Prophylaxis-Eligible Population

Rachel Mittelstaedt  1   2 , Sanjat Kanjilal  3   4 , David Helekal  2 , Gregory K Robbins  1 , Yonatan H Grad  2
Affiliations

Staphylococcus aureus Tetracycline Resistance and Co-resistance in a Doxycycline Postexposure Prophylaxis-Eligible Population

Rachel Mittelstaedt et al. J Infect Dis. .

Abstract

Among doxycycline postexposure prophylaxis (doxy-PEP)-eligible men, Staphylococcus aureus tetracycline nonsusceptibility is more prevalent than in the overall population and is associated with resistance to trimethoprim-sulfamethoxazole and clindamycin. Doxy-PEP may select for multidrug-resistant S aureus, underscoring the importance of surveillance.

Keywords: Staphylococcus aureus; doxy-PEP; doxycycline postexposure prophylaxis.

PubMed Disclaimer

Conflict of interest statement

Potential conflicts of interest . All authors: No reported conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.

Figures

Figure 1.
Figure 1.
Cohort identification schematic. Abbreviations: HIV, human immunodeficiency virus; PrEP, preexposure prophylaxis.
See this image and copyright information in PMC

Update of

References

    1. Centers for Disease Control and Prevention . Sexually transmitted infections surveillance 2023. Atlanta, GA: US Department of Health and Human Services, 2024.
    1. Luetkemeyer AF, Donnell D, Dombrowski JC, et al. . Postexposure doxycycline to prevent bacterial sexually transmitted infections. N Engl J Med 2023; 388:1296–306. - PMC - PubMed
    1. Bachmann LH, Barbee LA, Chan P, et al. . CDC clinical guidelines on the use of doxycycline postexposure prophylaxis for bacterial sexually transmitted infection prevention, United States, 2024. MMWR Recomm Rep 2024; 73:1–8. - PMC - PubMed
    1. Jo J-H, Harkins CP, Schwardt NH, et al. . Alterations of human skin microbiome and expansion of antimicrobial resistance after systemic antibiotics. Sci Transl Med 2021; 13:eabd8077. - PMC - PubMed
    1. Kenyon C. Doxycycline post-exposure prophylaxis could theoretically select for resistance to various antimicrobials in 19 pathobionts: an in silico analysis. Int J Infect Dis 2024; 142:106974. - PubMed

MeSH terms

Substances