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Meta-Analysis
. 2025 Jun;48(6):1839-1845.
doi: 10.1038/s41440-024-02072-0. Epub 2024 Dec 24.

Updated meta-analysis for antihypertensive treatment guided by home blood pressure compared to treatment based on office blood pressure: systematic review

Tatsuya Maruhashi #  1 , Yukako Tatsumi #  2 , Michihiro Satoh  3   4 , Yusuke Kobayashi  5   6 , Yukako Ogoyama  7 , Atsushi Sakima  8 , Hisatomi Arima  9 , Takayoshi Ohkubo  10
Affiliations
Meta-Analysis

Updated meta-analysis for antihypertensive treatment guided by home blood pressure compared to treatment based on office blood pressure: systematic review

Tatsuya Maruhashi et al. Hypertens Res. 2025 Jun.

Abstract

Home blood pressure (BP) measurement is widely used, and home BP plays a central role in hypertension management in clinical practice in Japan. We updated the systematic review to determine whether home BP-based antihypertensive treatment is superior to office BP-based treatment in improving clinical outcomes, including BP levels, in adult patients with essential hypertension. A literature search identified 14 randomized controlled trials (RCTs). The results of meta-analysis revealed that home BP-based antihypertensive treatment was significantly associated with greater reductions in ambulatory systolic BP by 2.73 mmHg (95% confidence interval [CI], -5.23 to -2.22 mmHg; p = 0.03) and ambulatory diastolic BP by 1.61 mmHg (95% CI, -3.21 to -0.01 mmHg; p = 0.05) compared to office BP-based treatment. No RCTs evaluating cardiovascular outcomes other than ambulatory BP reduction were identified. Consistent with the previous review, this updated meta-analysis revealed home BP-based antihypertensive treatment is strongly recommended over office BP-based treatment for BP control in patients with essential hypertension.

Keywords: Ambulatory blood pressure; Home blood pressure; Meta-analysis; Office blood pressure.

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Conflict of interest statement

Compliance with ethical standards. Conflict of interest: TO received honoraria (lecture fee) and a joint research grant from Omron Healthcare Co., Ltd.

References

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