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. 2025 Feb:82:103634.
doi: 10.1016/j.scr.2024.103634. Epub 2024 Dec 17.

Generation of induced pluripotent stem cell lines TRNDi037-A and TRNDi038-A from two patients with Alagille syndrome carrying heterozygous JAG1 mutations

Elena F Evans  1 , Guibin Chen  1 , Ivan Pavlinov  1 , Xiuli Huang  1 , Kaari Linask  2 , Chengyu Liu  3 , Alexander Rodriguez Lopez  1 , Melissa A Gilbert  4 , Nancy B Spinner  4 , Steven Rodemse  5 , Karsten Baumgärtele  5 , Catherine Z Chen  1 , Jizhong Zou  2 , Wei Zheng  6
Affiliations

Generation of induced pluripotent stem cell lines TRNDi037-A and TRNDi038-A from two patients with Alagille syndrome carrying heterozygous JAG1 mutations

Elena F Evans et al. Stem Cell Res. 2025 Feb.

Abstract

Human induced pluripotent stem cell (iPSC) lines TRNDi037-A and TRNDi038-A were generated from the lymphoblastoid cell lines (LCL) of two patients with different heterozygous JAG1 variants resulting in Alagille syndrome (ALGS). ALGS is a rare genetic disease of haploinsufficiency that affects the formation of the bile duct, in addition to other symptoms. These ALGS iPSC lines can be used to model ALGS and aid in the identification of therapeutics to treat patients with ALGS.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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